Inhibition of neurogenic inflammation in abortive migraine treatment

  • Egilius L. H. Spierings
Part of the Progress in Inflammation Research book series (PIR)


Neurogenic inflammation is mediated through the release of peptides, called neuropeptides, from the sensory nerve fibers involved in nociception. It comprises two processes, plasma-protein extravasation and neurogenic vasodilation, mediated predominantly by substance P and calcitonin gene-related peptide, respectively. Substance P is released from the unmyelinated C fibers and opens up post-capillary venules by acting on neurokinin-1 receptors, allowing the extravasation of plasma proteins. Calcitonin gene-related peptide, on the other hand, is released from the small myelinated Aθ fibers and dilates the arterioles by stimulating receptors of its own.


Dura Mater Trigeminal Ganglion Cortical Spreading Depression Neurogenic Inflammation Headache Relief 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Egilius L. H. Spierings
    • 1
  1. 1.Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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