Mediators and their receptors involved in neurogenic inflammation

  • Dimos D. Mitsikostas
Part of the Progress in Inflammation Research book series (PIR)


The trigeminal system is the basic neuronal system that transmits nociceptive information from the cranial structures, via the trigeminal ganglion, to the trigeminal nucleus caudalis [1]. Based on their histochemical and functional properties, the trigeminal ganglion cells are divided into two groups: approximately one-third project large, myelinated A-fibers and are mostly sensitive to mechanical stimulation; the remaining two-thirds project small, unmyelinated Aδ- and C-fibers and are nociceptive. The nerve cells projecting the small fibers can be further divided into two groups of approximately equal size. One subgroup contains calcitonin gene-related peptide and substance P as well as their receptors and also receptors for nerve growth factor. The remaining cells have a distinct chemical phenotype, are non-peptidergic, and carry receptors for the neurotrophic factor derived from the glial cell line [2].


Nerve Growth Factor Trigeminal Ganglion Neurogenic Inflammation Trigeminal Nucleus Caudalis Trigeminovascular System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Dimos D. Mitsikostas
    • 1
  1. 1.Headache ClinicAthens Naval HospitalAthensGreece

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