Models of neurogenic inflammation as it relates to migraine

  • Uwe Reuter
  • Guy Arnold
Part of the Progress in Inflammation Research book series (PIR)


For more than half a century, migraine was believed to be a vascular disorder with the aura attributed to cerebral vasoconstriction and ischemia and the headache to dilation and inflammation of extracranial arteries. However, there is mounting evidence that cortical spreading depression is the mechanism underlying the migraine aura and that (neurogenic) inflammation is more important than vasodilation in the migraine headache. This chapter focuses on the experimental models related to the putative migraine mechanisms of cortical spreading depression and neurogenic inflammation (Tab. 1).


Dura Mater Trigeminal Ganglion Vasoactive Intestinal Polypeptide Migraine Headache Cortical Spreading Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Uwe Reuter
    • 1
  • Guy Arnold
    • 1
  1. 1.Charité, Neurologische Klinik und PoliklinikHumboldt Universität zu BerlinBerlinGermany

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