Neurogenic inflammation in the pathogenesis of migraine

  • David W. Dodick
Part of the Progress in Inflammation Research book series (PIR)


Migraine is a prevalent and disabling disorder, which affects approximately 12% of the population of the United States [1]. The pathogenesis of the headache involves pain-sensitive cranial structures, possibly including the dura mater and large cerebral blood vessels and their trigeminal and cervical innervation [2]. The innervation of these structures is mediated primarily by the tentorial nerve, a branch of the ophthalmic nerve or first division of the trigeminal nerve, which also provides cutaneous innervation for the forehead and anterior vertex.


Cluster Headache Dura Mater Trigeminal Ganglion Migraine Headache Migraine Without Aura 
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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • David W. Dodick
    • 1
  1. 1.Department of NeurologyMayo ClinicScottsdaleUSA

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