Skip to main content
SpringerLink
Log in

Neurogenic inflammation in the pathogenesis of migraine

  • Chapter
Migraine: A Neuroinflammatory Disease?

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Migraine is a prevalent and disabling disorder, which affects approximately 12% of the population of the United States [1]. The pathogenesis of the headache involves pain-sensitive cranial structures, possibly including the dura mater and large cerebral blood vessels and their trigeminal and cervical innervation [2]. The innervation of these structures is mediated primarily by the tentorial nerve, a branch of the ophthalmic nerve or first division of the trigeminal nerve, which also provides cutaneous innervation for the forehead and anterior vertex.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lipton RB, Stewart WF (1993) Migraine in the United States: epidemiology and health-care utilization. Neurology 43: 6–10

    Google Scholar 

  2. Goadsby PJ, Zagami AS, Lambert GA (1991) Neural processing of craniovascular pain: a synthesis of the central structures involved in migraine. Headache 31: 365–371

    Article  PubMed  CAS  Google Scholar 

  3. Wolff HG (1963) Headache and other head pain. Oxford University Press, New York

    Google Scholar 

  4. Mayberg MR, Zervas NT, Moskowitz MA (1984) Trigeminal projections to supratentorial pial and durai blood vessels in cats demonstrated by horseradish peroxidase histochemistry. J Comparative Neur 223: 46–56

    Article  CAS  Google Scholar 

  5. Mayberg MR, Langer RS, Zervas NT, Moskowitz MA (1981) Perivascular meningeal projections from cat trigeminal ganglia: possible pathway for vascular headaches in man. Science 213: 228–230

    Article  PubMed  CAS  Google Scholar 

  6. Dimitriadou V, Buzzi MG, Theoharides TC, Moskowitz MA (1992) Ultrastructural evidence for neurogenically mediated changes in blood vessels of the rat dura mater and tongue following antidromic trigeminal stimulation. Neuroscience 48: 187–203

    Article  PubMed  CAS  Google Scholar 

  7. Markowitz S, Saito K, Moskowitz MA (1987) Neurogenically mediated leakage of plasma proteins occurs from blood vessels in the dura mater but not brain. J Neurosci 7: 4129–4136

    PubMed  CAS  Google Scholar 

  8. Dimitriadou V, Buzzi MG, Moskowitz MA (1991) Trigeminal sensory fiber stimulation induces morphological changes in rat dura mater mast cells. Neuroscience 44: 97–112

    Article  PubMed  CAS  Google Scholar 

  9. Edvinsson L, Hara H, Uddman R (1989) Retrograde tracing of nerve fibers to the rat middle cerebral artery with true blue: co-localization with different peptides. J Cerebral Blood Flow Metabol 9: 212–218

    Article  CAS  Google Scholar 

  10. Saria AL, Lundberg J, Skofitsch G et al (1983) Vascular leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and antigen challenge. Naunyn Schmiedebergs Arch Parmacol 324: 212–218

    Article  CAS  Google Scholar 

  11. Cutrer FM, Limroth V, Waeber C et al (1997) New targets for antimigraine drug development. In: PJ Goadsby, SD Silberstein (eds): Headache. Butterworth-Heinemann, Boston, 59–72

    Google Scholar 

  12. Goadsby PJ, Edvinsson L, Ekman R (1988) Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 23: 193–196

    Article  PubMed  CAS  Google Scholar 

  13. Goadsby PJ, Edvinsson L (1993) The trigeminovascular system and migraine: studies characterising cerebrovascular and neuropeptide changes seen in man and cat. Ann Neu-rol 33: 48–56

    CAS  Google Scholar 

  14. Edvinnson L, Goadsby PJ (1998) Neuropeptides in headache. Eur J Neurol 5: 329–341

    Article  Google Scholar 

  15. Cutrer FM, Moussaoui S, Garret C, Moskowitz MA (1995) The non-peptide neurokinin-1 antagonist, RPR 100893, decreases c-fos expression in trigeminal nucleus caudalis following noxious chemical meningeal stimulation. Neuroscience 64: 741–750

    Article  PubMed  CAS  Google Scholar 

  16. Shepheard SL, Williamson DJ, Williams J et al (1995) Comparison of the effects of sumatriptan and the NK-1 antagonist CP-99,994 on plasma extravasation in dura mater and c-fos mRNA expression in trigeminal nucleus caudalis of rats. Neuropharmacol 34: 255–261

    Article  CAS  Google Scholar 

  17. Shepheard SL, Williamson DJ, Hill RG, Hargreaves RJ (1993) The non-peptide NK-1 receptor antagonist RP 67580 blocks neurogenic plasma extravasation in the dura mater of rats. Br J Pharmacol 108: 11–12

    Article  PubMed  CAS  Google Scholar 

  18. Gitter BD, Bruns RF, Howbert JJ et al (1995) Pharmacological characterization of LY303870: a novel, potent, and selective nonpeptide substance P (neurokinin 1) receptor antagonist. J Pharmacol Exp Ther 275: 737–744

    PubMed  CAS  Google Scholar 

  19. Goldstein DJ, Wang O, Saper JR (1997) Ineffectiveness of NK-1 antagonist in acute migraine: a crossover study. Cephalalgia 17: 785–790

    Article  PubMed  CAS  Google Scholar 

  20. Connor HE, Bertin L, Gillies S et al (1998) Clinical evaluation of a novel, potent, CNS penetrating NK1 receptor antagonist in the acute treatment of migraine (abstract). Cephalalgia 18: 293

    Article  Google Scholar 

  21. Mantyh PW, DeMaster E, Malhotra A et al (1995) Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 268: 1629–1632

    Article  PubMed  CAS  Google Scholar 

  22. Goldstein DJ, Offen WW, Klein EG, Phebus LA (1999) Lanepitant, an NK-1 antagonist, in migraine prophylaxis (abstract). Cephalalgia 19: 377

    Google Scholar 

  23. Saria A (1999) The tachykinin NK1 receptor in the brain: pharmacology and putative functions. Eur J Pharmacol 375: 51–60

    Article  PubMed  CAS  Google Scholar 

  24. Zagami AS, Goadsby PJ, Edvinsson L (1990) Stimulation of the superior sagittal sinus in the cat causes release of vasoactive peptides. Neuropeptides 16: 69–75

    Article  PubMed  CAS  Google Scholar 

  25. Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28: 183–187

    Article  PubMed  CAS  Google Scholar 

  26. Goadsby PJ, Edvinsson L (1993) The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in man and cat. Ann Neurol 33: 48–56

    Article  PubMed  CAS  Google Scholar 

  27. Couch JR, Saper J, Meloche JP (1996) Treatment of migraine with BMS 180048: response at 2 hours. Headache 36: 523–530

    Article  PubMed  Google Scholar 

  28. Knight YE, Edvinsson L, Goadsby PJ (1997). Blockade of release of CGRP after superior sagittal sinus stimulation in cat: a comparison of avitriptan and CP122,288 (abstract). Cephalalgia 17: 248

    Google Scholar 

  29. Roon K, Diener HC, Ellis P et al (1997) CP-122,288 blocks neurogenic inflammation, but is not effective in aborting migraine attacks: results of two controlled clinical trials (abstract). Cephalalgia 17: 245

    Google Scholar 

  30. Fanciullaci M, Alessandri M, Fegini M et al (1995) Increases in plasma calcitonin gene-related peptide from extracerebral circulation during nitroglycerin-induced cluster headache attack. Pain 60: 119–123

    Article  Google Scholar 

  31. Goadsby PJ, Edvinsson L (1994) Human in vivo evidence for trigeminovascular activation in cluster headache. Brain 117: 427–434

    Article  PubMed  Google Scholar 

  32. Ashina M, Bendtsen L, Jensen R et al (1999) Increased plasma levels of calcitonin gene-related peptide in migraine (abstract). Cephalalgia 19: 346

    Google Scholar 

  33. Tajti J, Uddman R, Møller F et al (1999) Neuronal messenger molecules and peptide receptors distribution in the human trigeminal ganglion (abstract). Cephalalgia 19: 392

    Google Scholar 

  34. Van Rossum D, Hanisch UK, Quirion R (1997) Neuroanatomical localization, pharmacologic characterization and functions of CGRP, related peptides and their receptors. Neurosci Biobehav Rev 21: 649–678

    Article  PubMed  Google Scholar 

  35. Jansen-Olesen I, Mortensen A, Edvinsson L (1996) Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibers and induces vasodilation of human cerebral arteries concomitant with activation of adenylyl cyclase. Cephalalgia 16: 310–316

    Article  PubMed  CAS  Google Scholar 

  36. Moreno MJ, Abounader R, Lantin S et al (2000) CGRP-mediated dilations in human cerebral arteries are potently antagonized by BIBN4096BS, a selective CGRP receptor antagonist (abstract). Cephalalgia 20: 272–273

    Google Scholar 

  37. Lassen LH, Jacobson VB, Pedersen PA et al (1999) hCGRP-induced headache in migraineurs (abstract). Cephalalgia 19: 316

    Google Scholar 

  38. De Hoon JNJM, Pikkers P, Smits P et al (1999) Calcitonin gene-related peptide induces vasodilation by nitric oxide (abstract). Cephalalgia 19: 315

    Google Scholar 

  39. De Hoon JNJM, Pikkers P, Smits P et al (1999) Calcitonin gene-related peptide-induced vasodilation does not involve the activation of potassium channels in man (abstract). Cephalalgia 19: 397

    Google Scholar 

  40. Jansen-Olesen I, Edvinnson L (2000) Cephalic neurovascular transmitters and receptors. In: J Olesen, P Tfelt-Hansen, KMA Welch (eds): The headaches. Raven Press, New York, 87–98

    Google Scholar 

  41. Hasselblatt M, Köhler J, Volles E, Ehrenreich H (1999) Simultaneous monitoring of endothelin-1 and vasopressin plasma levels in migraine. Neuroreport 10: 423–425

    Article  PubMed  CAS  Google Scholar 

  42. May A, Gijsman HJ, Wallnofer A et al (1996) Endothelin antagonist bosentan blocks neurogenic inflammation, but is not effective in aborting migraine attacks. Pain 67: 375–378

    Article  PubMed  CAS  Google Scholar 

  43. Earl NL, McDonald SA, Lowy MT (1999) Efficacy and tolerability of the neurogenic inflammation inhibitor, 4991W93, in the acute treatment of migraine (abstract). Cephalalgia 19: 357

    Google Scholar 

  44. Roon KI, Olesen J, Diener HC et al (2000) No acute antimigraine efficacy of CPP122,288, a highly potent inhibitor of neurogenic inflammation: results of two randomized, double blind, placebo-controlled clinical trials. Ann Neurol 47: 238–241

    Article  PubMed  CAS  Google Scholar 

  45. Nissila M, Parkkola R, Sonninen P, Salonen R (1996) Intracerebral arteries and gadolinium enhancement in migraine without aura (abstract). Cephalalgia 16: 363

    Google Scholar 

  46. May A, Shepheard S, Wessing A et al (1998) Retinal plasma extravasation can be evoked by trigeminal stimulation in rat but does not occur during migraine attacks. Brain 121: 1231–1237

    Article  PubMed  Google Scholar 

  47. Pappagalo M, Szabo Z, Esposito G et al (1999) Imaging neurogenic inflammation in patients with migraine headaches (abstract). Neurology 52: A274–A275

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA

    David W. Dodick

Authors
  1. David W. Dodick
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Egilius L. H. Spierings

  2. Headache Unit, Department of Neurology, FundaciĂłn Hospital AlcorcĂłn Juan Carlos I University, Madrid, Spain

    Margarita Sánchez del Río

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Basel AG

About this chapter

Cite this chapter

Dodick, D.W. (2002). Neurogenic inflammation in the pathogenesis of migraine. In: Spierings, E.L.H., Sánchez del Río, M. (eds) Migraine: A Neuroinflammatory Disease?. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8131-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8131-9_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9449-4

  • Online ISBN: 978-3-0348-8131-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation