Abstract
Until recently, molecular systematics was dominated by analyses of DNA sequences or derived peptide sequences generated by traditional cloning or PCR techniques. Many of these early studies were dependent upon only a single form of biological information, primary sequence. With the advent of genomic biology, multiple layers of biological information are available for comparative inquiry. It is possible to compare genomic DNA sequence and structure, mRNA sequence (via cDNAs), alternate transcript mRNAs, and peptide sequence with or without post-translation modifications. In the future it should also be possible to generate comparative, phylogenetically relevant data from 3-dimensional protein models, as well as from protein interaction assays, and possibly even microarrays. With the accelerating pace of data collection, it may be more time-consuming to assemble publicly available data than to generate one’s own complement of pertinent data.
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Wray, C.G. (2002). Complex Model Organism Genome Databases. In: DeSalle, R., Giribet, G., Wheeler, W. (eds) Techniques in Molecular Systematics and Evolution. Methods and Tools in Biosciences and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8125-8_7
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DOI: https://doi.org/10.1007/978-3-0348-8125-8_7
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-7643-6257-7
Online ISBN: 978-3-0348-8125-8
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