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Bone morphogenetic proteins in periodontal regeneration

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Bone Morphogenetic Proteins

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Periodontitis is a chronic inflammatory disease causing breakdown of the periodontal tissues eventually resulting in tooth loss. Successful periodontal reconstruction includes regeneration of a variety of tissues including cementum, periodontal ligament, alveolar bone and gingiva. Wound healing is thought to be regulated by various growth and differentiation factors, such as bone morphogenetic proteins (BMPs), and cytokines. The expression of these biologic mediators following bone and soft tisue injury is thought to regulate the process of repair and/or regeneration. For example, BMPs are known to be expressed during bone repair following fracture [1] and during periodontal wound healing [2]. The rationale for growth factor administration in periodontics is to enhance and/or accelerate the physiological wound healing capacity that may be insufficient to promote a complete healing of the affected structures. Over the past decade numerousin vitroandin vivostudies have been performed to elucidate the role of growth and differentiation factors in periodontal wound healing. Several of these factors are now available in recombinant form and can be produced in a highly pure form in a large scale production.

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Author information

Authors and Affiliations

  1. Department of Restorative Dentistry and Periodontology, University of Kiel, Arnold Heller Str. 16, Kiel, 24105, Germany

    Søren Jepsen

  2. Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Str. 16, Kiel, 24105, Germany

    Hendrik Terheyden

Authors
  1. Søren Jepsen
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  2. Hendrik Terheyden
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Editors and Affiliations

  1. School of Medicine, Laboratory for Mineralized Tissues, Salata 11, Zagreb, 10000, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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© 2002 Springer Basel AG

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Jepsen, S., Terheyden, H. (2002). Bone morphogenetic proteins in periodontal regeneration. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8121-0_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8121-0_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9446-3

  • Online ISBN: 978-3-0348-8121-0

  • eBook Packages: Springer Book Archive

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