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BMPs in articular cartilage repair

  • Chapter
Bone Morphogenetic Proteins

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Over the past several decades, in clinical orthopedic work, from open Magnusson “housecleaning” arthroplasty to the autologous chondrocyte implantation, much has been learned about articular cartilage and its physiological capacity to restore itself. To date, no technique has been completely successful in restoring normal regenerative articular cartilage. Techniques to treat chondral defects include abrasion, drilling, microfracture technique, tissue autografts, allografts, and cell transplantation [1–12]. Bone marrow stimulation techniques such as abrasion, drilling, and microfractures produce only fibrocartilage and therefore do not offer a longterm cure. Subchondral bone plate microfracture (abrasion or drilling) has shown to enhance chondral resurfacing by providing a suitable environment for tissue regeneration and taking advantage of the body’s own healing potential. The formation of a fibrin clot (“super clot”) containing desired pluripotential stem cells is stimulated [10]. This clot then differentiates and remodels, resulting in a durable fibrocartilage repair tissue [1]. Perichondral and periostal interposition grafts produce repair tissue that is similar to hyaline cartilage but also lack the mechanical durability. Like bone marrow stimulation techniques, interposition grafts introduce precursor cells, which have a tendency to differentiate along lines other than cartilage [7]. Autologous osteochondral transplant systems have shown encouraging results, but graft matching and contouring to the recipient articular surface proved to be difficult.

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Authors and Affiliations

  1. Departments of Orthopaedic Surgery and Anatomy, School of Medicine, Clinics of Surgery, Orthopaedic Surgery and Ophthalmology, Veterinary Faculty, University of Zagreb, Salata 11, Zagreb, 10000, Croatia

    Mislav Jelic, Marko Pecina, Miroslav Haspl, Anton Brkic & Slobodan Vukicevic

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  1. Mislav Jelic
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  2. Marko Pecina
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  3. Miroslav Haspl
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  4. Anton Brkic
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  5. Slobodan Vukicevic
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Editors and Affiliations

  1. School of Medicine, Laboratory for Mineralized Tissues, Salata 11, Zagreb, 10000, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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© 2002 Springer Basel AG

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Jelic, M., Pecina, M., Haspl, M., Brkic, A., Vukicevic, S. (2002). BMPs in articular cartilage repair. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8121-0_13

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  • DOI: https://doi.org/10.1007/978-3-0348-8121-0_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9446-3

  • Online ISBN: 978-3-0348-8121-0

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