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Bone morphogenetic proteins and the synovial joints

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Bone Morphogenetic Proteins

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Bone morphogenetic proteins (BMPs) are involved in a broad array of morpho-genetic processes. These span from the specification of the dorso-ventral body axis to patterning, organogenesis and differentiation of most tissues. Nevertheless, the initial discovery of BMPs as protein preparations that induce ectopically andin vivoa cascade of endochondral bone formation in rats, has strongly stimulated the study of their role in the development of the skeleton and in the patterning of the synovial joints [1–3]. In addition, with their remarkable cartilage and bone morphogenetic activity, BMPs represent an attractive therapeutic option for skeletal and joint disorders. Indeed, growing scientific evidence supports the concept that tissue repair and regeneration recapitulates to a certain extent the process of tissue formation during embryonic development. Taking advantage of the expanding knowledge in the field of developmental biology to define potential new targeted therapeutic approaches, the role of BMPs in the development of the skeleton and in particular in the patterning and differentiation of joint tissues becomes increasingly clinically relevant.

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Authors and Affiliations

  1. Laboratory of Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Herestraat 49, Leuven, B-3000, Belgium

    Frank P. Luyten, Rik Lories, Dirk De Valck, Cosimo De Bari & Francesco Dell’Accio

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  1. Frank P. Luyten
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  2. Rik Lories
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  3. Dirk De Valck
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  4. Cosimo De Bari
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  5. Francesco Dell’Accio
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Editors and Affiliations

  1. School of Medicine, Laboratory for Mineralized Tissues, Salata 11, Zagreb, 10000, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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Luyten, F.P., Lories, R., De Valck, D., De Bari, C., Dell’Accio, F. (2002). Bone morphogenetic proteins and the synovial joints. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8121-0_12

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  • DOI: https://doi.org/10.1007/978-3-0348-8121-0_12

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9446-3

  • Online ISBN: 978-3-0348-8121-0

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