Skip to main content
SpringerLink
Log in

Biosensors

  • Chapter
Analytical Biotechnology

Part of the book series: Methods and Tools in Biosciences and Medicine ((MTBM))

Abstract

A biosensor is an analytical device which uses biologically material to detect chemical species directly without the need for complex sample processing. The major impetus driving the significant increase of interest in biosensors over the past decade has been the attraction of utilizing the high specificity and sensitivity offered by biomolecules and biological systems.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Urban G, Jobst G, Kohl F, et al. (1991) Miniaturized thin film biosensors using covalently immobilized glucose oxidase. Biosensors and Bioelectronics 6: 555–562

    Article  CAS  Google Scholar 

  2. Schalkhammer Th, Lobmaier C, Ecker B, Wakolbinger W, Kynclova E, Hawa G, Pittner F. (1994) Microfabricated Glucose-, Lactate-, Glutamate-and Glutamine Thin Film Biosensors. Sensors and Actuators B 18–19: 587–591

    Google Scholar 

  3. Turner APF, Karube I, Wilson GS (1987) Biosensors-fundamentals and applications, Oxford Science Publications, London

    Google Scholar 

  4. Freitag R (1993) Applied biosensors Carr Opin Biotechnol 4: 75–79

    Article  CAS  Google Scholar 

  5. Doblhoff-Dier O, Rechnitz GA (1989) Amperometric method for the determination of superoxide dismutase activity at physiological pH. Analytica Chimica Acta 222: 247–252

    Article  CAS  Google Scholar 

  6. Karyakin AA, Karyakina EE, Schuh-mann W, et al. (1994) New amperometric dehydrogenase electrodes based on electrocatalytic NADH-oxidation at poly(Methylene Blue)-modified electrodes. Electroanalysis 6: 821–829

    Article  CAS  Google Scholar 

  7. Mann Buxbaum E, Hawa G, Schalkham-mer Th, et al. (1992) Construction of electrochemical biosensors: Coupling techniques and surface interactions of proteins and nucleic acids on electrode surfaces. In: G Costa, S Miertus (eds) Trends in electrochemical biosensors: World Scientific, Singapur/New York/ London/Hong Kong, pp 69–84

    Google Scholar 

  8. Pittner F, Schalkhammer Th, Mann-Buxbaum E, Urban G. (1990) Miniaturized thin film biosensors. Microsystem Technologies 90: 124–125

    Google Scholar 

  9. Moser I, Schalkhammer Th, Mann-Buxbaum E, et al. (1992) Advanced immobilization and protein techniques on thin-film biosensors. Sensors and Actuators B7: 356–362

    CAS  Google Scholar 

  10. Schalkhammer Th, Mann-Buxbaum E, Urban G, Pittner F. (1990) Electrochemical biosensors on thin film metals and conducting polymers. J Chromatography 510: 355

    Article  CAS  Google Scholar 

  11. Williams RA, Blanch HW (1994) Covalent immobilization of protein monolayers for biosensor applications. Biosens Bioelectron 9: 159–167

    Article  CAS  Google Scholar 

  12. Ahluwalia A, De Rossi D, Ristori C, et al. (1992) A comparative study of protein immobilization techniques for optical immunosensors. Biosen Bioelectron 7: 207–214

    Article  CAS  Google Scholar 

  13. Schalkhammer Th, Mann Buxbaum E, Moser I, et al. (1992) New immobiliza-tion techniques for the preparation of thin film biosensors. In: U Sleytr, P Messner, D Pum, M Sara (eds) Immobilized Macromolecules Springer Verlag Berlin, Heidelberg, New York p. 119–139

    Google Scholar 

  14. Lobmaier C, Schalkhammer Th, Hawa G, et al. (1995) Photo-structurized electrochemical biosensors for bioreactor control and measurement in body fluids. J Mol Recognition 8: 146–150

    Article  CAS  Google Scholar 

  15. Schalkhammer Th, Lobmaier C, Pittner F, et al. (1995) A metal island coated polymer sensor for direct determination of chaotropic agents. Mikrochimica Acta 121: 259–268

    Article  CAS  Google Scholar 

  16. Collioud A, Clemente JF, Sanger M, Sigrist H (1993) Oriented and covalent immobilization of target molecules to solid supports: Synthesis and application of a light-activatable and thiol-reactive cross-linking reagent. Bioconjugate Chem 4: 528–536

    Article  CAS  Google Scholar 

  17. Schalkhammer Th, Mann-Buxbaum E, Urban G, Pittner F (1991) Electrochemical glucose sensors on permselective non-conducting substituted pyrrole polymers. Sensors and Actuators B4: 273–281

    CAS  Google Scholar 

  18. Bartlett PN, Cooper JM (1993) A review of the immobilisation of enzymes in electropolymerized films. J Electroanal Chem 362: 1–12

    Article  CAS  Google Scholar 

  19. Heiduschka P, Gopel W, Beck W, et al. (1996) Microstructured peptide-functionalised surfaces by electrochemical polymerisation. Chem Eur J 2: 667–672

    Article  CAS  Google Scholar 

  20. Lukachova LV, Karyakin AA, Ivanova YN, et al. (1998) Non-aqueous enzymology approach for improvement of reagent-less mediator based glucose biosensor. Analyst 123: 1981–1986

    Article  CAS  Google Scholar 

  21. Schalkhammer Th, Hartig A, Pittner F, Moser I. (1991) Surface modification of platinum based electrochemical thin film electrodes for DNA biosensors. Microsystem Technologies 91: 76–81

    Google Scholar 

  22. Karyakin AA, Bobrova OA, Lukachova LV, Karyakina EE (1996) Potentiometric biosensors based on polyaniline semiconductor films. Sensors & Actuators B 33: 34–38

    Article  Google Scholar 

  23. Karyakina EE, Neftyakova LV, Karyakin AA (1994) A novel potentiometric glucose biosensor based on polyaniline semiconductor film. Analyt Letters 27(15): 2871–2882

    Article  CAS  Google Scholar 

  24. Cornell BA, Braach-Maksvytis VLB, King LG, et al. (1997) A biosensor that uses ion-channel switches. Nature 387: 580–583

    Article  CAS  Google Scholar 

  25. Weiss-Wichert C, Smetazko M, Saba M, Schalkhammer Th (1997) A new analytical device based on gated ion channels. J Biomol Screening 2 (1): 11–18

    Article  CAS  Google Scholar 

  26. Schalkhammer Th, Weiss-Wichert C, Smetazko M, Saba M (1997) Ion channels in artificial bolaamphiphilic membranes deposited on sensor chips - optical detection in an ion channel based biosensor. SPIE 2976:117–128

    Article  CAS  Google Scholar 

  27. Neumann-Spallart C, Pittner F, Schalk-hammer Th (1997) Immobilization of active facilitated glucose transporters (GLUT-1) in supported biological membranes. Appl Biochem Biotechnol 68: 47–63

    Article  Google Scholar 

  28. Berggren C, Johansson G (1997) Capacitance measurements of antibody-antigen interactions in a flow system. Anal Chem 69 (18): 3651–3657

    Article  CAS  Google Scholar 

  29. Ngeh-Ngwainbi J, Suleiman AA, Guibault GG (1990) Piezoelectric crystal biosensor. Biosens Bioelectron 5: 13–26

    Article  CAS  Google Scholar 

  30. Wirth M, Gabor F, Schalkhammer Th, Pittner F (1995) Determination of mitoxantrone via fiber-optic device. Mikrochimica Acta 121: 87–93

    Article  CAS  Google Scholar 

  31. Trettnak W, Wolfbeis OS (1989) A new type of fiber optic biosensor based on the intrinsic fluorescence of immobilized flavoproteins. Proc SPIE 1172: 287–292

    Google Scholar 

  32. Moreno-Bondi MC, Wolfbeis OS, Leiner MJP, Schaffar BPH (1990) Oxygen optrode for use in a fiber optic glucose biosensor. Anal Chem 62: 2377–2380

    Article  CAS  Google Scholar 

  33. Vogel H, Sanger M, Sigrist h (1995) Covalent attachment of functionalized lipid bilayers to planar waveguides for measuring protein binding to biomimetic membranes. Prot Sci 4: 2532–2544

    Article  Google Scholar 

  34. Duschl C, Vogel h (1994) A new class of thiolipids for the attachment of lipid bi-layers on gold surfaces. Langmuir 10: 197–210

    Article  Google Scholar 

  35. Stelzle M, Weissmuller G, Sackmann E (1993) On the application of supported bilayers as receptive layer for biosensors with electrical detection. J Phys Chem 97: 2974–2981

    Article  CAS  Google Scholar 

  36. Gustafson I, Artursson E, Ohlsson PA (1995) Retained activities of some membrane proteins in stable lipid bilayers on a solid support. Biosens Bioelectron 10: 463–476

    Article  Google Scholar 

  37. Sambles JR (1991) Optical excitation of surface plasmons. Contemporay Physics 32: 3

    Google Scholar 

  38. Fägerstam LG, Frostell-Karlsson A, Karlsson R, et al. (1992) Biospecific interaction analysis using surface plasmon resonance detection applied to kinetic, binding site and concentration analysis. J Chromatogr 597: 397–410

    Article  Google Scholar 

  39. Gershon PD, Khilko S (1995) Stable chelating linkage for reversible immobilization of oligohistidine tagged proteins in the BlAcore surface plasmon resonance detector. J Immunol Meth 183: 65–76

    Article  CAS  Google Scholar 

  40. Harris RD (1996) Waveguide surface plasmon resonance biosensor, PhD Thesis, Southampton

    Google Scholar 

  41. Harris RD, Wilkinson JS (1995) Wave-guide surface plasmon resonance sensor. Sens Actuators B 29: 261–267

    Article  Google Scholar 

  42. O’Shannessy DJ (1994) Determination of kinetic rate and equilibrium constants for macromolecular interactions: A critique of the surface plasmon resonance literature. Curr Opin Biotechnol 5: 65–71

    Article  Google Scholar 

  43. Loibner AP, Doblhoff-Dier O, Zach N, et al. (1994) Automated glucose measurement with micro structured thin layer biosensors for the control of fermentation processes. Sensors and Actuators B 18–19: 603–606

    Article  Google Scholar 

  44. Mayer C, Frauer A, Schalkhammer Th, Pittner F (1999) Enzyme based flow injection analysis system for glutamine and glutamate in mammalian cell culture media. Anal Biochem 268: 110–116

    Article  CAS  Google Scholar 

Download references

Authors
  1. Thomas G. M. Schalkhammer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. TUDELFT, Kluyver Lab. for Biotechnology, Julianalaan 67, BC Delft, 2628, The Netherlands

    Thomas G. M. Schalkhammer

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Basel AG

About this chapter

Cite this chapter

Schalkhammer, T.G.M. (2002). Biosensors. In: Schalkhammer, T.G.M. (eds) Analytical Biotechnology. Methods and Tools in Biosciences and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8101-2_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8101-2_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-7643-6589-9

  • Online ISBN: 978-3-0348-8101-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation