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The role of IL-6 and related cytokines in myocardial remodeling and inflammation – implication for cardiac hypertrophy and heart failure

  • Chapter
Inflammation and Cardiac Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cardiac remodeling is a complex dynamic process occurring in reaction to an insult to the myocardium and contributing to the development of congestive heart failure (CHF). Left ventricular remodeling occurs either in response to a loss of cardiac cells as observed after myocardial infarction (MI), or in response to a hemodynamic overload as is the case in patients with chronic hypertension. The remodeling of cardiac tissue is characterized by the presence of hypertrophy, apoptosis and extracellular matrix re-organization and is associated with an inflammatory response [1-3]. Among the different factors involved in the development of cardiac remodeling, recent evidence has suggested a role for various pleiotropic cytokines, including interleukin-6 (IL-6), cardiotrophin-1 (CT-1) and others. Through the stimulation of tyrosine-kinase specific receptors, these cytokines lead to the activation of fetal gene regulatory programs, cardiac cell growth and survival.

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Authors and Affiliations

  1. Institut de Recherches Servier, 11 Rue des Moulineaux, Suresnes, F-92150, France

    Antoine Bril

  2. Pharmacology Department, WP42-209, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, USA

    Giora Z. Feuerstein

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  1. Antoine Bril
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Editors and Affiliations

  1. Pharmacology Department WP42-209, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, USA

    Giora Z. Feuerstein

  2. Cardiovascular Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue EBRC 307, Boston, MA, 02115, USA

    Peter Libby

  3. Winters Center for Heart Failure Research, 6565 Fannin MS 524, Houston, TX, 77030, USA

    Douglas L. Mann

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Bril, A., Feuerstein, G.Z. (2003). The role of IL-6 and related cytokines in myocardial remodeling and inflammation – implication for cardiac hypertrophy and heart failure. In: Feuerstein, G.Z., Libby, P., Mann, D.L. (eds) Inflammation and Cardiac Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8047-3_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8047-3_7

  • Publisher Name: Birkhäuser, Basel

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