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Inflammation and Cardiac Diseases pp 21–53Cite as

Birkhäuser

Inflammation and coronary artery disease

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The complications of atherosclerosis are associated with a high incidence of morbidity and mortality in Western societies [1]. Coronary atherosclerosis is now considered a complex inflammatory process in response to the retention of specific atherogenic lipoproteins in the arterial wall. In addition to the localized immune response, there is emerging evidence that systemic inflammatory markers may have a diagnostic value in predicting acute cardiac events. Among the many risk factors for atherosclerosis, hyperlipidemia is thought the most influential on inflammatory processes along with specific immunological factors. Recent animal studies suggest that the induction of atherosclerosis is closely linked to lipoprotein abnormalities since genetic derangements of systemic or localized immunity alone do not initiate the disease. Although genetically engineered animals have furthered the understanding of the role of inflammation in atherosclerosis, the relevance of these findings to disease progression in humans are not as clear. This chapter will discuss the role of inflammation in the evolution of varying coronary lesions, particularly those associated with acute coronary syndromes. In addition, potential systemic factors that may influence inflammation in the vessel wall in relation to plaque instability will also be addressed.

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Authors and Affiliations

  1. Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825, 16th Street NW, Washington, DC, 20306-6000, USA

    Renu Virmani, Frank D. Kolodgie, Allen P. Burke & Andrew Farb

  2. Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA

    Herman K. Gold & Aloke V. Finn

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  1. Renu Virmani
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  2. Frank D. Kolodgie
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  3. Allen P. Burke
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  4. Andrew Farb
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  5. Herman K. Gold
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  6. Aloke V. Finn
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Editors and Affiliations

  1. Pharmacology Department WP42-209, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, USA

    Giora Z. Feuerstein

  2. Cardiovascular Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue EBRC 307, Boston, MA, 02115, USA

    Peter Libby

  3. Winters Center for Heart Failure Research, 6565 Fannin MS 524, Houston, TX, 77030, USA

    Douglas L. Mann

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Virmani, R., Kolodgie, F.D., Burke, A.P., Farb, A., Gold, H.K., Finn, A.V. (2003). Inflammation and coronary artery disease. In: Feuerstein, G.Z., Libby, P., Mann, D.L. (eds) Inflammation and Cardiac Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8047-3_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8047-3_3

  • Publisher Name: Birkhäuser, Basel

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