Skip to main content
SpringerLink
Log in

Role of chemokines in the pathogenesis of congestive heart failure

  • Chapter
Inflammation and Cardiac Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

  • 119 Accesses

Abstract

In 1990, Levin et al. [1] reported that high circulating levels of tumor necrosis factor (TNF-a) were found in patients with severe congestive heart failure (CHF), and suggested that this cytokine is involved in the pathogenesis of cardiac failure. Since then, increasing amounts of clinical and experimental data have accumulated to support a role of inflammatory mediators in the pathogenesis of myocardial dysfunction in CHF. The present chapter will review the current evidence on the involvement of chemokines, a subgroup of cytokines with chemo-attractant properties, in the mechanisms that lead to myocardial dysfunction and the development of CHF.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Levine B, Kalman J, Mayer L, Fillit HM, Packer M (1990) Elevated circulating levels oftumor necrosis factor in severe chronic heart failure.N Engl J Med 323: 236–241

    Article  PubMed  CAS  Google Scholar 

  2. Adams DH, Lloyd A R (1997) Chemokines: leucocyte recruitment and activation cytokines.Lancet349: 490–495

    Article  PubMed  CAS  Google Scholar 

  3. Luster AD (1998) Chemokines—chemotactic cytokines that mediate inflammation.NEngl J Med338: 436–445

    Article  CAS  Google Scholar 

  4. Baggiolini M (2001) Chemokines in pathology and medicine.J Intern Med250: 91–104

    Article  PubMed  CAS  Google Scholar 

  5. Gerard C, Rollins BJ (2001) Chemokines and disease.Nat Immunol2: 108–115

    Article  PubMed  CAS  Google Scholar 

  6. Krishnaswamy G, Kelley J, Yerra L, Smith JK., Chi DS (1999) Human endothelium as a source of multifunctional cytokines: Molecular regulation and possible role in human disease.J Interferon Cytokine Res19: 91–104

    Article  PubMed  CAS  Google Scholar 

  7. Wang X, Yue TL, Ohlstein EH, Sung CP, Feuerstein GZ (1996) Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response.J Biol Chem271: 24286–24293

    Article  PubMed  CAS  Google Scholar 

  8. Yue TL, Wang X, Sung CP, Olson B, McKenna PJ, Gu JL, Feuerstein GZ (1994) Interleukin-8. A mitogen and chemo-attractant for vascular smooth muscle cells.Circ Res75: 1–7

    Article  PubMed  CAS  Google Scholar 

  9. Gu L, Tseng SC, Rollins BJ (1999) Monocyte chemo-attractant protein-1.Chem Immunol72: 7–29

    Article  PubMed  CAS  Google Scholar 

  10. Zhang Y, Ernst CA, Rollins BJ (1996) MCP-1: Structure/activity analysis.Methods10: 93–103

    Article  PubMed  CAS  Google Scholar 

  11. Shin WS, Szuba A, Rockson SG (2002) The role of chemokines in human cardiovascular pathology: enhanced biological insights.Atherosclerosis160: 91–102

    Article  PubMed  CAS  Google Scholar 

  12. Aukrust P, Damas JK, Gullestad L, Froland SS (2001) Chemokines in myocardial failure — pathogenic importance and potential therapeutic targets.Clin Exp Immunol124: 343–345

    Article  PubMed  CAS  Google Scholar 

  13. Walz A, Peveri P, Aschauer H, Baggiolini M (1987) Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes.Biochem Biophys Res Commun149: 755–761

    Article  PubMed  CAS  Google Scholar 

  14. Zlotnik A, Yoshie 0 (2000) Chemokines: A new classification system and their role in immunity.Immunity12: 121–127

    Article  PubMed  CAS  Google Scholar 

  15. Schwarz MK, Wells TN (2002) New therapeutics that modulate chemokine networks.Nat RevDrug Discov1: 347–358

    Article  CAS  Google Scholar 

  16. Thelen M (2001) Dancing to the tune of chemokines.Nat Immunol2: 129–134

    Article  PubMed  CAS  Google Scholar 

  17. Rodriguez-Frade JM, Mellado M, Martinez A (2001) Chemokine receptor dimerization: Two are better than one.Trends Immunol22: 612–617

    Article  PubMed  CAS  Google Scholar 

  18. Laudanna C, Campbell JJ, Butcher EC (1996) Role of Rho in chemo-attractant-activated leukocyte adhesion through integrins.Science271: 981–983

    Article  PubMed  CAS  Google Scholar 

  19. Premack BA, Schall TJ (1996) Chemokine receptors: Gateways to inflammation and infection.Nat Med2: 1174–1178

    Article  PubMed  CAS  Google Scholar 

  20. Peters W, Charo IF (2001) Involvement of chemokine receptor 2 and its ligand, monocyte chemo-attractant protein-1, in the development of atherosclerosis: Lessons from knockout mice.Curr Opin Lipidol12: 175–180

    Article  PubMed  CAS  Google Scholar 

  21. Sasayama S, Okada M, Matsumori A (2000) Chemokines and cardiovascular diseases.Cardiovasc Res45: 267–269

    Article  PubMed  CAS  Google Scholar 

  22. Kukielka GL, Smith CW, LaRosa GJ, Manning AM, Mendoza LH, Daly TJ, Hughes BJ, Youker KA, Hawkins HK, Michael LH (1995) Interleukin-8 gene induction in the myocardium after ischemia and reperfusionin vivo. J Clin Invest95: 89–103

    Article  CAS  Google Scholar 

  23. Kakio T, Matsumori A, Ono K, Ito H, Matsushima K, Sasayama S (2000) Roles and relationship of macrophages and monocyte chemotactic and activating factor/monocyte chemo-attractant protein-1 in the ischemic and reperfused rat heart.Lab Invest80: 1127–1136

    Article  PubMed  CAS  Google Scholar 

  24. Furukawa Y, Matsumori A, Ohashi N, Shioi T, Ono K, Harada A, Matsushima K, Sasayama S (1999) Anti-monocyte chemo-attractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries.Circ Res84: 306–314

    Article  PubMed  CAS  Google Scholar 

  25. Tomita H, Egashira K, Kubo-Inoue M, Usui M, Koyanagi M, Shimokawa H, Takeya M, Yoshimura T, Takeshita A (1998) Inhibition of NO synthesis induces inflammatory changes and monocyte chemo-attractant protein-1 expression in rat hearts and vessels.Arterioscler Thromb Vasc Biol18: 1456–1464

    Article  PubMed  CAS  Google Scholar 

  26. Usui M, Egashira K, Tomita H, Koyanagi M, Katoh M, Shimokawa H, Takeya M, Yoshimura T, Matsushima K, Takeshita A (2000) Important role of local angiotensin II activity mediatedviaType 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats.Circulation101: 305–310

    Article  PubMed  CAS  Google Scholar 

  27. Egashira K, Koyanagi M, Kitamoto S, Ni W, Kataoka C, Morishita R, Kaneda Y, Akiyama C, Nishida KI, Sueishi K et al (2000) Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: Blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis.FASEB J14: 1974–1978

    Article  PubMed  CAS  Google Scholar 

  28. Schecter AD, Rollins BJ, Zhang YJ, Charo IF, Fallon JT, Rossikhina M, Giesen PL, Nemerson Y, Taubman MB (1997) Tissue factor is induced by monocyte chemo-attractant protein-1 in human aortic smooth muscle and THP-1 cells.J Biol Chem272: 28568–28573

    Article  PubMed  CAS  Google Scholar 

  29. Boisvert WA, Curtiss LK, Terkeltaub RA (2000) Interleukin-8 and its receptor CXCR2 in atherosclerosis.Immunol Res21: 129–137

    Article  PubMed  CAS  Google Scholar 

  30. Abi-Younes S, Sauty A, Mach F, Sukhova GK, Libby P, Luster AD (2000) The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques.Circ Res86: 131–138

    Article  PubMed  CAS  Google Scholar 

  31. Mach F, Sauty A, larossi AS, Sukhova GK, Neote K, Libby P, Luster AD (1999) Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.J Clin Invest104: 1041–1050

    Article  PubMed  CAS  Google Scholar 

  32. Hague NS, Zhang X, French DL, Li J, Poon M, Fallon JT, Gabel BR, Taubman MB, Koschinsky M, Harpel PC (2000) CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipoprotein(a) in human vascular endothelial cells.Circulation102: 786–792

    Article  Google Scholar 

  33. Sasayama S, Matsumori A, Kihara Y (1999) New insights into the pathophysiological role for cytokines in heart failure.Cardiovasc Res42: 557–564

    Article  PubMed  CAS  Google Scholar 

  34. Aukrust P, Ueland T, Lien E, Bendtzen K, Muller F, Andreassen, A K, Nordoy I, Aass H, Espevik T, Simonsen S et al (1999) Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.Am J Cardiol83: 376–382

    Article  PubMed  CAS  Google Scholar 

  35. Blum A, Miller H (2001) Pathophysiological role of cytokines in congestive heart failure.Annu Rev Med52: 15–27

    Article  PubMed  CAS  Google Scholar 

  36. Dinarello CA, Pomerantz BJ (2001) Proinflammatory cytokines in heart disease.Blood Puri f19: 314–321

    Article  CAS  Google Scholar 

  37. Seino Y, Ikeda U, Sekiguchi H, Morita M, Konishi K, Kasahara T, Shimada K. (1995) Expression of leukocyte chemotactic cytokines in myocardial tissue.Cytokine 7:301–304

    Article  PubMed  CAS  Google Scholar 

  38. Aukrust P, Ueland T, Muller F, Andreassen A K, Nordo I, Aass H, Kjekshus J, Simonsen S, Froland SS, Gullestad L (1998) Elevated circulating levels of C-C chemokines in patients with congestive heart failure.Circulation97: 1136–1143

    Article  PubMed  CAS  Google Scholar 

  39. Lehmann MH, Kuhnert H, Muller S, Sigusch HH (1998) Monocyte chemoattractant protein 1 (MCP-1) gene expression in dilated cardiomyopathy.Cytokine 10:739–746

    Article  PubMed  CAS  Google Scholar 

  40. Damas JK, Gullestad L, Ueland T, Solum NO, Simonsen S, Froland SS, Aukrust P (2000) CXC-chemokines, a new group of cytokines in congestive heart failure—possible role of platelets and monocytes.Cardiovasc Res45: 428–436

    Article  PubMed  CAS  Google Scholar 

  41. Damas JK, Eiken HG, Oie E, Bjerkeli V, Yndestad A, Ueland T, Tonnessen T, Geiran OR, Aass H, Simonsen S et al (2000) Myocardial expression of CC- and CXCchemokines and their receptors in human end-stage heart failure.Cardiovasc Res47: 778–787

    Article  PubMed  CAS  Google Scholar 

  42. Damas JK, Gullestad L, Aass H, Simonsen S, Fjeld JG, Wikeby L, Ueland T, Eiken HG, Froland SS, Aukrust P (2001) Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure—modulatory effect of intravenous immunoglobulin.J Am Coll Cardiol38: 187–193

    Article  PubMed  CAS  Google Scholar 

  43. Shioi T, Matsumori A, Kihara Y, Inoko M, Ono K, Iwanaga Y, Yamada T, Iwasaki A, Matsushima K, Sasayama S (1997) Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor/monocyte chemo-attractant protein-1 in the hypertrophied and failing heart with pressure overload.Circ Res81: 664–671

    Article  PubMed  CAS  Google Scholar 

  44. Kolattukudy PE, Quach T, Bergese S, Breckenridge S, Hensley J, Altschuld R, Gordillo G, Klenotic S, Orosz C, Parker-Thornburg J (1998) Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle.Am J Pathol152: 101–111

    PubMed  CAS  Google Scholar 

  45. Behr TM, Wang X, Aiyar N, Coatney RW, Li X, Koster P, Angermann CE, Ohlstein E, Feuerstein GZ, Winaver J (2000) Monocyte chemo-attractant protein-1 is upregulated in rats with volume-overload congestive heart failure.Circulation102: 1315–1322

    Article  PubMed  CAS  Google Scholar 

  46. Winaver J, Hoffman A, Burnett JCJ, Haramati A (1988) Hormonal determinants of sodium excretion in rats with experimental high-output heart failure.Am J Physiol254: R776–R784

    PubMed  CAS  Google Scholar 

  47. Abassi ZA, Brodsky S, Karram T, Dobkin I, Winaver J, Hoffman A (2001) Temporal changes in natriuretic and antinatriuretic systems after closure of a large arteriovenous fistula.Cardiovasc Res51: 567–576

    Article  PubMed  CAS  Google Scholar 

  48. Damas JK, Aukrust P, Ueland T, Odegaard A, Eiken HG., Gullestad L, Sejersted OM, Christensen G (2001) Monocyte chemoattractant protein-1 enhances and interleukin-10 suppresses the production of inflammatory cytokines in adult rat cardiomyocytes.Basic Res Cardiol96: 345–352

    Article  PubMed  CAS  Google Scholar 

  49. Okada M, Matsumori A, Ono K, Furukawa Y, Shioi T, Iwasaki A, Matsushima K, Sasayama S (1998) Cyclic stretch upregulates production of interleukin-8 and monocyte chemotactic and activating factor/monocyte chemo-attractant protein-1 in human endothelial cells.Arterioscler Thromb Vasc Biol18: 894–901

    Article  PubMed  CAS  Google Scholar 

  50. Capers Q, Alexander RW, Lou P, De Leon H, Wilcox JN, Ishizaka N, Howard AB, Taylor WR (1997) Monocyte chemo-attractant protein-1 expression in aortic tissues of hypertensive rats.Hypertension30: 1397–1402

    Article  PubMed  CAS  Google Scholar 

  51. Hernandez-Presa M, Bustos C, Ortego M, Tunon J, Renedo G, Ruiz-Ortega M, Egido J (1997) Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappaB activation, monocyte chemo-attractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis.Circulation95: 1532–1541

    Article  PubMed  CAS  Google Scholar 

  52. Bush E, Maeda N, Kuziel WA, Dawson TC, Wilcox JN, DeLeon H, Taylor W R (2000) CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension.Hypertension36: 360–363

    Article  PubMed  CAS  Google Scholar 

  53. Griendling KK, Ushio-Fukai M, Lassegue B, Alexander RW (1997) Angiotensin II signaling in vascular smooth muscle. New concepts.Hypertension29: 366–373

    Article  PubMed  CAS  Google Scholar 

  54. Dzau VJ (1987) Renal and circulatory mechanisms in congestive heart failure.Kidney Int31: 1402–1415

    Article  PubMed  CAS  Google Scholar 

  55. Dzau VJ (1993) Tissue renin-angiotensin system in myocardial hypertrophy and failure.Arch Intern Med153: 937–942

    Article  PubMed  CAS  Google Scholar 

  56. Yamazaki T, Komuro I, Yazaki Y (1999) Role of the renin-angiotensin system in cardiac hypertrophy. AmJ Cardil83: 53H–57H

    Article  CAS  Google Scholar 

  57. Pieruzzi F, Abassi ZA, Keiser HR (1995) Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure.Circulation92: 3105–3112

    Article  PubMed  CAS  Google Scholar 

  58. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone M A Jr., Luster AD, Luscinskas FW, Rosenzweig A (1999) MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.Nature398: 718–723

    Article  PubMed  CAS  Google Scholar 

  59. Balligand JL, Cannon PJ (1997) Nitric oxide synthases and cardiac muscle. Autocrine and paracrine influences.Arterioscler Thromb Vasc Biol17: 1846–1858

    Article  PubMed  CAS  Google Scholar 

  60. Gealekman O, Abassi Z, Rubinstein I, Winaver J, Binah O (2002) Role of myocardial inducible nitric oxide synthase in contractile dysfunction and beta-adrenergic hypo-responsiveness in rats with experimental volume-overload heart failure.Circulation105: 236–243

    Article  PubMed  CAS  Google Scholar 

  61. Gharaee-Kermani M, Denholm EM, Phan SH (1996) Costimulation of fibroblast colla-gen and transforming growth factor betal gene expression by monocyte chemo-attractant protein-1viaspecific receptors.J Biol Chem271: 17779–17784

    Article  PubMed  CAS  Google Scholar 

  62. Yamamoto T, Eckes B, Mauch C, Hartmann K, Krieg T (2000) Monocyte chemo-attractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop.J Immunol164: 6174–6179

    PubMed  CAS  Google Scholar 

  63. Spinale FG (2002) Matrix metalloproteinases: regulation and dysregulation in the failing heart.Circ Res90: 520–530

    Article  PubMed  CAS  Google Scholar 

  64. Bradham WS, Moe G, Wendt KA, Scott AA, Konig A, Romanova M, Naik G, Spinale FG (2002) TNF-alpha and myocardial matrix metalloproteinases in heart failure: relationship to LV remodeling. AmJ Physiol Heart Circ Physiol282: H1288–H1295

    CAS  Google Scholar 

  65. Soejima H, Ogawa H, Yasue H, Kaikita K, Takazoe K, Nishiyama K, Misumi, K, Miyamoto S, Yoshimura M, Kugiyama K, Nakamura S, Tsuji I (1999) Angiotensin-converting enzyme inhibition reduces monocyte chemo-attractant protein-1 and tissue factor levels in patients with myocardial infarction. J AmColl Cardiol34: 983–988

    Article  PubMed  CAS  Google Scholar 

  66. Romano M, Diomede L, Sironi M, Massimiliano L, Sottocorno M, Polentarutti N, Guglielmotti A, Albani D, Bruno A, Fruscella P et al (2000) Inhibition of monocyte chemotactic protein-1 synthesis by statins.Lab Invest80: 1095–1100

    Article  PubMed  CAS  Google Scholar 

  67. Koyanagi M, Egashira K, Kitamoto S, Ni W, Shimokawa H, Takeya M, Yoshimura T, Takeshita A (2000) Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis.Circulation102: 2243–2248

    Article  PubMed  CAS  Google Scholar 

  68. Carter PH (2002) Chemokine receptor antagonism as an approach to anti-inflammatory therapy: “just right” or plain wrong?Curr Opin Chem Biol6: 510–525

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology & Biophysics, Faculty of Medicine, Technion, P.O. Box 9649, Haifa, 31096, Israel

    Joseph Winaver & Zaid Abassi

  2. Department of Cardiology, Medizinische Poliklinik, University of Wuerzburg, Klinikstr. 6, Wuerzburg, 97084, Germany

    Thomas M. Behr

Authors
  1. Joseph Winaver
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas M. Behr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zaid Abassi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pharmacology Department WP42-209, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, USA

    Giora Z. Feuerstein

  2. Cardiovascular Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue EBRC 307, Boston, MA, 02115, USA

    Peter Libby

  3. Winters Center for Heart Failure Research, 6565 Fannin MS 524, Houston, TX, 77030, USA

    Douglas L. Mann

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Basel AG

About this chapter

Cite this chapter

Winaver, J., Behr, T.M., Abassi, Z. (2003). Role of chemokines in the pathogenesis of congestive heart failure. In: Feuerstein, G.Z., Libby, P., Mann, D.L. (eds) Inflammation and Cardiac Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8047-3_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8047-3_21

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9419-7

  • Online ISBN: 978-3-0348-8047-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation