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Identification and role of inflammatory oxygen free radicals in cardiac ischemia and reperfusion injury

  • Chapter
Book cover Inflammation and Cardiac Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Prolonged myocardial ischemia results in a variety of severe cellular, metabolic and ultra-structural damages. It is therefore generally accepted that reperfusion is an absolute prerequisite for the survival of ischemic tissue. However, reperfusion may precipitate arrhythmias, cause myocardial stunning and accelerate necrotic process. Oxygen free radicals have been suggested as possible mediators of reperfusioninduced injury and there is circumstantial evidence that supports this hypothesis. Indirect evidence in support of this concept derives from studies in which antioxidant enzymes, enzyme inhibitors, free radical scavengers and iron chelators are able to protect against reperfusion injury in a number of experimental studies.In vivopolymorphonuclear leukocytes (PMNs) have been hypothesized to induce and to amplify the process of reperfusion injury in post-ischemic myocardium. Within vivo models, there are many different cellular and humoral factors making it difficult to determine the importance of specific components in the pathogenesis of myocardial injury. Both ischemia and reperfusion promote the expression of pro-inflammatory gene products and bioactive agents. Furthermore, ischemia induces a pro-inflammatory state that increases tissue vulnerability towards further injury during reperfusion.

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Authors and Affiliations

  1. Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Expérimentales, Institut Fédératif de Recherche n° 100, Facultés de Médecine et de Pharmacie, Université de Bourgogne, 7 Bd Jeanne d’Arc, Dijon cedex, BP 87900, 21079, France

    Catherine Vergely, Gaëlle Clermont, Sandrine Lecour, Antoine Bri & Luc Rochette

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  1. Catherine Vergely
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  2. Gaëlle Clermont
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  3. Sandrine Lecour
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  4. Antoine Bri
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  5. Luc Rochette
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Editor information

Editors and Affiliations

  1. Pharmacology Department WP42-209, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, USA

    Giora Z. Feuerstein

  2. Cardiovascular Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue EBRC 307, Boston, MA, 02115, USA

    Peter Libby

  3. Winters Center for Heart Failure Research, 6565 Fannin MS 524, Houston, TX, 77030, USA

    Douglas L. Mann

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© 2003 Springer Basel AG

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Vergely, C., Clermont, G., Lecour, S., Bri, A., Rochette, L. (2003). Identification and role of inflammatory oxygen free radicals in cardiac ischemia and reperfusion injury. In: Feuerstein, G.Z., Libby, P., Mann, D.L. (eds) Inflammation and Cardiac Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8047-3_11

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  • DOI: https://doi.org/10.1007/978-3-0348-8047-3_11

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9419-7

  • Online ISBN: 978-3-0348-8047-3

  • eBook Packages: Springer Book Archive

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