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Inflammation and Cardiac Diseases pp 155–170Cite as

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Myocardial nitric oxide in cardiac remodeling

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Evidence has emerged that nitric oxide (NO) plays a role in the pathogenesis of myocardial failure. The effects of NO in heart failure, as in other clinical situations, may be either beneficial or deleterious. It has been hypothesized that NO at relatively low levels appears to modulate the response of the myocardium to potentially deleterious stimuli, and thus in some situations may offset the progression of myocardial failure. On the other hand, at higher levels NO has the ability to impair normal myocardial function and to exert direct toxic effects in the myocardium, as it can in other tissues. The effects of higher levels of NO may be relevant to a variety of situations in which myocardial NO is increased. These include conditions in which there is a clear inflammatory reaction such as sepsis, myocarditis, transplant rejection or acute infarction. There is also evidence that NO production is increased above physiologic levels in the myocardium of patients with chronic heart failure. These observations have led to the concern that with increasing levels, NO may contribute to the pathogenesis of myocardial failure, and thus change from a friend to a foe.

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Authors and Affiliations

  1. Myocardial Biology Unit, Boston University School of Medicine, Cardiovascular Division, Department of Medicine, Boston University Medical Center, 88 East Newton Street, D-8, Boston, MA, 02118, USA

    Flora Sam, Douglas B. Sawyer & Wilson S. Colucci

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  1. Flora Sam
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  2. Douglas B. Sawyer
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  3. Wilson S. Colucci
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Editors and Affiliations

  1. Pharmacology Department WP42-209, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, USA

    Giora Z. Feuerstein

  2. Cardiovascular Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue EBRC 307, Boston, MA, 02115, USA

    Peter Libby

  3. Winters Center for Heart Failure Research, 6565 Fannin MS 524, Houston, TX, 77030, USA

    Douglas L. Mann

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Sam, F., Sawyer, D.B., Colucci, W.S. (2003). Myocardial nitric oxide in cardiac remodeling. In: Feuerstein, G.Z., Libby, P., Mann, D.L. (eds) Inflammation and Cardiac Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8047-3_10

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  • DOI: https://doi.org/10.1007/978-3-0348-8047-3_10

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