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Mind over Matter - Regulation of Peripheral Inflammation by the CNS pp 149–176Cite as

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The skin as a model for the immunodulatory effects of corticotropin-releasing hormone

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The strategic location of the skin as the barrier between the environment and internal milieu determines its critical role in the preservation of body homeostasis [1].Thus, on the side facing the environment, the skin is continuously exposed to multiple noxious agents including the acute transfers of solar, thermal or mechanical energy. When these factors reach an intensity high enough to produce skin damage, several mechanisms rapidly come into play to restore the skin’s structural and functional integrity. Such mechanisms include the proliferative activity of the epidermis, the secretory activity of adnexal structures, and the activities of the pigmentary and the immune system, including its dermal vascular and mesenchymal components [1].

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Suite 509, 930 Madison Avenue, Memphis, TN, 38163, USA

    Andrzej Slominski & Alexander Pisarchik

  2. Department of Medicine, Southern Illinois University, Springfield, IL, USA

    Jacobo Wortsman

  3. Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, UK

    Elizabeth Linton

  4. Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland

    Blazej Zbytek

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  1. Andrzej Slominski
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  2. Jacobo Wortsman
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  1. Campus Benjamin Franklin Klinik für Anästhesiologie und operative Intensivmedizin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, Berlin, 12200, Germany

    Michael Schäfer  & Christoph Stein  & 

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Slominski, A., Wortsman, J., Linton, E., Pisarchik, A., Zbytek, B. (2003). The skin as a model for the immunodulatory effects of corticotropin-releasing hormone. In: Schäfer, M., Stein, C. (eds) Mind over Matter - Regulation of Peripheral Inflammation by the CNS. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8039-8_10

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  • DOI: https://doi.org/10.1007/978-3-0348-8039-8_10

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