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Heat shock proteins and rheumatoid arthritis

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Heat Shock Proteins and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

In this chapter we shall review the possible role of heat shock proteins (HSP) and chaperones in the pathogenesis of rheumatoid arthritis (RA). Although HSP/chapcrones are found in all cells, their expression is increased at times of cellular or tissue stress. It is under these conditions that new roles or functions for these proteins will become apparent. Hence, the first section of the review deals with the expression of HSP in the RA synovial membrane (SM). There then follow two sections dealing with the immune response to HSP by patients with RA. The first part considers the antibody responses and the second part the response at the T-cell level. In the third section, we consider the proposal by Roudier and his colleagues that bacterial HSP are involved in the pathogenesis of RA because of molecular mimicry with the shared epitope. This is an innovative concept worthy of separate discussion not least because it is being tested in the clinic. Finally, we review our work on BiP, the endoplasmic reticulum chaperone, which focuses on the concept that HSP/chapcrones may have immunomodulatory or anti-inflammatory effects when found extra-cellularly rather than solely being involved in pro-inflammatory events, which has been the prevailing view to date.

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  1. Department of Rheumatology, GKT School of Medicine, King’s College London, London, SE1 9RT, UK

    Gabriel S. Panayi & Valerie M. Corrigall

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  1. Gabriel S. Panayi
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  2. Valerie M. Corrigall
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  1. Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, Utrecht, 3584CL, The Netherlands

    Willem van Eden

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Panayi, G.S., Corrigall, V.M. (2003). Heat shock proteins and rheumatoid arthritis. In: van Eden, W. (eds) Heat Shock Proteins and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8028-2_9

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