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HSP60-peptide interference with CD94/NKG2 receptors

  • Chapter
Heat Shock Proteins and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

An efficient and sufficient inflammatory response mediated by cells belonging to both the innate and adaptive immune system, is crucial in order to clear infection and allow for tissue repair after damage. Natural killer (NK) cells are innate type of lymphocytes, which together with activated CD8+ T-cells mediates immune responses against many pathogens and tumors. These lymphocytes can survey tissues looking for evidence that a cell has been altered and thereby prevent pathogen invasion and/or tumor growth and metastasis. Upon encountering an altered cell, they have the option to either kill the cell directly through release of lytic granules and/or to produce cytokines. Rapidly accumulating data show that certain MHC Class I specific cell-surface receptors, known previously to critically regulate NK cell functions, appear on large numbers of CD8+ T-cells after activation [1-3].

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  1. In Silico R&D, Entelos Inc., 110 Marsh Drive, Foster City, CA, 94404, USA

    Kalle Söderström

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  1. Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, Utrecht, 3584CL, The Netherlands

    Willem van Eden

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Söderström, K. (2003). HSP60-peptide interference with CD94/NKG2 receptors. In: van Eden, W. (eds) Heat Shock Proteins and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8028-2_17

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  • DOI: https://doi.org/10.1007/978-3-0348-8028-2_17

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