Abstract
Mycobacterial infections constitute a major thread to cattle populations worldwide. The major mycobacterial infections are tuberculosis, caused by infection with M. bovis (MB), and paratuberculosis, caused by infection with M. avium ssp. paratuberculosis (MAP). Evidence of (bovine) tuberculosis goes back to before the domestication of cattle (8000-4000 BC), however the battle against mycobacteria was significantly boosted by the discovery of the tubercle bacillus in 1882 by Robert Koch [1, 2]. Bovine tuberculosis can reside in many different organs, although the pulmonary form is usually considered to be the “classical” form, the latter being restricted to the lung and its draining lymph nodes. The description of a chronic granulomatous infection of the small intestine in a cow, by Johne and Frottingham in 1895, was the first report on paratuberculosis; although at the time they considered it to be an unusual case of bovine tuberculosis [3]. Apart from the fact that MB and MAP have different tissue trophisms, they share many other characteristics. Both cause slow developing diseases, with a long asymptomatic period during which disease is spread between individuals, eventually causing a wasting syndrome in animals progressing to the clinical stage of the disease, months or more likely years after infection. Both diagnosis, especially in the early asymptomatic stages of the disease, as well as protective vaccination are notoriously difficult. Both diseases also represent a threat to human health as bovine tuberculosis is a zoonosis and, although still controversial, MAP has been implicated in the etiology of human Crohn’s Disease [1, 4].
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Koets, A.P. (2003). Mycobacterial heat shock proteins and the bovine immune system. In: van Eden, W. (eds) Heat Shock Proteins and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8028-2_15
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DOI: https://doi.org/10.1007/978-3-0348-8028-2_15
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