Abstract
The pharmaceutical industry is continuing to attempt double-digit growth rates driven by high market capitalization. Standard responses to this challenge have only provided limited impact. Besides scaling-up businesses through mergers or selective acquisitions of platform technologies or drug candidates, an increase of Research and Development (R&D) productivity still represents a sure approach to address this challenge.
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References
PhRMA (2000) Based on data from PhRMA Annual Survey and Standard & Poor’s Compustat, a division of McGraw-Hill
PhRMA Annual Survey (2000)
Report issued by Bain & Company Germany Inc. (2001)
Boston Consulting Group. A revolution in R&D. (2001)
DiMasi JA (2001) Risks in new drug development: approval success rates for investigational drugs. Clin Pharmacol Ther 69: 297–307
Report issued by the Tufts Center for the Study of Drug Development, Tufts University, Boston, MA, USA (1998)
Peck CC (1997) Drug development: improving the process. Food Drug Law J 52: 163–167
Drews J (2000) Drug discovery: a historical perspective. Science 287: 1960–1964
Ward SJ (2001) Impact of genomics in drug discovery. Biotechniques 31: 626–630
Cunningham MT (2000) Genomics and proteomics: the new millennium of drug discovery and devel-op. ment J Pharmacol Toxicol Methods 44: 291–300
Dongre AR, Opiteck G, Cosand WL et al (2001) Proteomics in the post-genome age. Biopolymers 60: 206–211
Augen J (2002) The evolving role of information technology in the drug discovery process. Drug Discov Today 7: 315–323
Davies EK, Richards WG (2002) The potential of Internet computing for drug discovery. Drug Discov Today 7: S99–S103
Lander ES, Linton LM, Birren B et al (2001) Initial sequencing and analysis of the human genome. Nature 409: 860–921
Venter JC, Adams MD, Myers EW et al (2001) The sequence of the human genome. Science 291: 1304–1351
National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, http://www.ncbi.nlm.nih.gov. (2002)
Searls DB (2000) Using bioinformatics in gene and drug discovery. Drug Discov Today 5: 135–143
Hogenesch JB, Ching KA, Batalov S et al (2001) A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes. Cell 106: 413–415
Wright FA, Lemon WJ, Zhao WD et al (2001) A draft annotation and overview of the human genome. Genome Biol 2: RESEARCH00251–002518
Duckworth DM, Sanseau P (2002) In silico identification of novel therapeutic targets. Drug Discov Today 7: S64–S69
Sanseau P (2001) Impact of human genome sequencing for in silico target discovery. Drug Discov Today 6: 316–323
Tang CM, Moxon ER (2001) The impact of microbial genomics on antimicrobial drug development. Annu Rev Genomics Hum Genet 2: 259–269
Herrmann R, Reiner B (1998) Mycoplasma pneumoniae and Mycoplasma genitalium: a comparison of two closely related bacterial species. Curr Opin Microbiol 1: 572–579
Noordewier MO, Warren PV (2001) Gene expression microarrays and the integration of biological knowledge. Trends Biotechnol 19: 412–415
Kennedy GC (2000) The impact of genomics on therapeutic drug development. EXS 89: 1–10
Gygi SP, Rochon Y, Franza BR et al (1999) Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19: 1720–1730
Loo JA, DeJohn DE, Du P et al (1999) Application of mass spectrometry for target identification and characterization. Med Res Rev 19: 307–319
Abuin A, Holt KH, Platt KA et al (2002) Full-speed mammalian genetics: in vivo target validation in the drug discovery process. Trends Biotechnol 20: 36–42
Tornell J, Snaith M (2002) Transgenic systems in drug discovery: from target identification to humanized mice. Drug Discov Today 7: 461–470
Sanseau P (2001) Transgenic gene knockouts: a functional platform for the industry. Drug Discov Today 6: 770–771
Dean NM (2001) Functional genomics and target validation approaches using antisense oligonucleotide technology. Curr Opin Biotechnol 12: 622–625
Tse E, Lobato MN, Forster A et al (2002) Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein. J Mol Biol 317: 85–94
Burley SK (2000) An overview of structural genomics. Nat Struct Biol 7 Suppl: 932–934
Service RF (2000) Structural genomics offers high-speed look at proteins. Science 287: 1954–1956
Dean PM, Zanders ED (2002) The use of chemical design tools to transform proteomics data into drug candidates. Biotechniques Suppl: 28–33
Willson TM, Jones SA, Moore JT et al (2001) Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism. Med Res Rev 21: 513–522
Lenz GR, Nash HM, Jindal S (2000) Chemical ligands, genomics and drug discovery. Drug Discov Today 5: 145–156
Hertzberg RP, Pope At (2000) High-throughput screening: new technology for the 21st century. Curr Opin Chem Biol 4: 445–451
Wolcke J, Ullmann D (2001) Miniaturized HTS technologies — uHTS. Drug Discov Today 6: 637–646
Wess G, Urmann M, Sickenberger B (2001) Medicinal Chemistry: Challenges and Opportunities. Angew Chem Int Ed Engl 40: 3341–3350
Drews J (2000) Drug discovery today — and tomorrow. Drug Discov Today 5: 2–4
Harvey AL (1999) Medicines from nature: are natural products still relevant to drug discovery? Trends Pharmacol Sci 20: 196–198
Sundberg SA (2000) High-throughput and ultra-high-throughput screening: solution-and cell-based approaches. Curr Opin Biotechnol 11: 47–53
Silverman L, Campbell R, Broach JR (1998) New assay technologies for high-throughput screening. Curr Opin Chem Biol 2: 397–403
Schneider G, Böhm HJ (2002) Virtual screening and fast automated docking methods. Drug Discov Today 7: 64–70
Toledo-Sherman LM, Chen D (2002) High-throughput virtual screening for drug discovery in parallel. Curr Opin Drug Discov Devel 5: 414–421
Shuker SB, Hajduk PJ, Meadows RP et al (1996) Discovering high-affinity ligands for proteins: SAR by NMR. Science 274: 1531–1534
Brennan MB (2000) Drug Discovery: filtering out failures early in the game. Chemical & Engineering News 78: 63–73
Bachmann KA, Ghosh R (2001) The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions. Curr Drug Metab 2: 299–314
Vogel HG (2001) Drug Discovery and Evaluation. Pharmacological Assays. Springer-Verlag, Berlin Heidelberg
Beresford AP, Selick HE, Tarbit MH (2002) The emerging importance of predictive ADME simulation in drug discovery. Drug Discov Today 7: 109–116
Butina D, Segall MD, Frankcombe K (2002) Predicting ADME properties in silico: methods and models. Drug Discov Today 7: S83–S88
Roses AD (2001) Pharmacogenetics. Hum Mol Genet 10: 2261–2267
Roses AD (2000) Pharmacogenetics and the practice of medicine. Nature 405: 857–865
Vesell ES (2000) Advances in pharmacogenetics and pharmacogenomics. J Clin Pharmacol 40: 930–938
McCarthy JJ, Hilfiker R (2000) The use of single-nucleotide polymorphism maps in pharmacogenomics. Nat Biotechnol 18: 505–508
Tomita M (2001) Whole-cell simulation: a grand challenge of the 21st century. Trends Biotechnol 19: 205–210
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Giersiefen, H., Hilgenfeld, R., Hillisch, A. (2003). Modern methods of drug discovery: An introduction. In: Hillisch, A., Hilgenfeld, R. (eds) Modern Methods of Drug Discovery. EXS, vol 93. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7997-2_1
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DOI: https://doi.org/10.1007/978-3-0348-7997-2_1
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