Summary
In this chapter, we focus on diagnostic laboratory methods that are necessary and suitable for providing physicians with a timely and accurate diagnosis of fungal diseases. After discussing some pre-analytical aspects, the complete set of methods, i.e., microscopy, histopathology, culture, antigen detection, DNA detection, and antibody detection, is concisely described. Identification techniques depend on the fungal group involved. Therefore, separate paragraphs are dedicated to the identification of yeasts and filamentous fungi, which include moulds, dermatophytes, and dimorphic fungi.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.W. Denning, E.G.V. Evans, C.C. Kibbler, M.D. Richardson, M.M. Roberts, T.R. Rogers, D.W. Warnock and R.E. Warren: Eur. J. Clin. Microbiol. Infect. Dis. 16, 424 (1997).
A. Glasmacher, G. Marklein, G. Just-Niibling, C. Leuter and S. Ewig: Dtsch. Med. Wschr. 123, 157 (1998).
M.R. McGinnis (ed.): Laboratory Handbook of Medical Mycology, Academic Press Inc, New York 1980.
H.P.R. Seeliger and T. Heymer (eds.): Diagnostik pathogener Pilze des Menschen and seiner Umwelt, Thieme, Stuttgart, New York 1981.
E.W. Koneman and G.D. Roberts (eds.): Practical Laboratory Mycology, Williams & Wilkins, Baltimore 1985.
J.W. Rippon (ed.): Medical Mycology, W.B. Saunders Company, Philadelphia 1988.
E.G.V. Evans and M.D. Richardson (eds.): Medical Mycology. A practical approach, IRL Press, Oxford 1989.
C. Seebacher and R. Blaschke-Hellmessen (eds.): Mykosen. Epidemiologie - Diagnostik- Therapie, Gustav Fischer Verlag, Jena 1990.
K.J. Kwon-Chung and J.W. Bennett (eds.): Medical Mycology, Lea & Febiger, Philadel-phia 1992.
W. Meinhof and J. Maüler, in: F. Burkhardt (ed.): Mikrobiologische Diagnostik, Georg Thieme Verlag, Stuttgart, New York 1992, 441–486.
M.D. Richardson and D.W. Warnock (eds.): Fungal infection. Diagnosis and manage-ment, Blackwell Scientific Publications, London 1993.
D.W. Denning (ed.): Opportunistic fungal infections, Science Press, London 1994.
J.T. Crissey, H. Lang and L.C. Parish (eds.): Manual of medical mycology, Blackwell Sci-entific, Cambridge MA 1995.
E.S. Beneke and A.L. Rogers (eds.): Medical Mycology, Star Publishing Company, Bel-mont CA 1996.
C.C. Kibbler, D.W.R. Mackenzie and F.C. Odds (eds.): Principles and practice of clinical mycology John Wiley & Sons, Chichester 1996.
G. Darai, M. Handermann, E. Hinz and H.-G. Sonntag (eds.): Lexikon der Infektions-krankheiten des Menschen, Springer-Verlag, Berlin, Heidelberg, New York 1997.
F.W. Fischer and N.B. Cook (eds.): Fundamentals of diagnostic mycology, W.B. Saunders, Philadelphia 1998.
P.R. Murray, E.J. Baron, M.A. Pfaller, F.C. Tenover and R.H. Yolken (eds.): Manual of clin-ical microbiology, ASM Press, Washington 1999.
I.F. Salkin, M.R. McGinnis, C.R. Cooper, J.W. Rippon and E.S. Beneke: J. Med. Vet. Mycol. 32 (Suppl. 1), 309, 1994.
J.A. Horvath and S. Dummer: Am. J. Med. 100, 171 (1996).
R. Kappe and D. Rimek, in: A.A. Brakhage, B. Jahn and A. Schmidt (eds.): Aspergillus fumi-gates, Karger, Basel 1999, 88–104.
G. Haase, M. Borg-von Zeppelin, H. Bernhardt, W. Fegeler, D. Harmsen, R. Kappe, H.C. Korting, A. Kuijpers, R. Rüchel, M. Schaller et al., in: H. Mauch and R. Lüitticken (eds.): MIQ. Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik, Urban & Fischer München, Jena 2001, Band 14.
J.Y. Richmond and R.W. McKinney (eds.): Primary containment for biohazards: Selec-tion, installation and use of biological safety cabinets, U.S. government printing office, Washington, D.C. 1995.
G.S. de Hoog: Mycoses 39, 407 (1996).
G. Haase, M. Borg-von Zeppelin, H. Bernhardt, W. Fegeler, D. Harmsen, R. Kappe, H.C. Korting, A. Kuijpers, R. Rüchel, M. Schaller et al., in: H. Mauch and R. Lütticken (eds.): MIQ. Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik, Urban & Fischer München, Jena 2001, Band 15.
G. H. Hageage Jr. and B.J. Harrington: Lab. Med. 15, 109 (1984).
R. Rachel and M. Schaffrinski: J. Clin. Microbiol. 37, 2694 (1999).
S. Ascioglu, J.H. Rex, B. de Pauw, J.E. Bennett, J. Bille, F. Crokaert, D.W. Denning, J.P. Don-nelly, J.E. Edwards, Z. Erjavec et al.: Clin. Infect. Dis. 34, 7 (2002).
R.G. Grocott: Am. J. Clin. Pathol. 25, 975 (1955).
K.B. Raper and F.I. Fennell (eds.): The genus Aspergillus, Williams & Wilkins, Baltimore 1965.
E.I. Boutati and E.J. Anaissie: Blood 90, 999 (1997).
J.A. Ribes, C.L. Vanover-Sams and D.J. Baker: Clin. Microbiol. Rev. 13, 236 (2000).
R.D. Baker (ed.), in: E. Uehlinger (ed.): Handbuch der speziellen pathologischen Anatomie and Histologie, Band III/5, Springer-Verlag, New York 1971.
F.W. Chandler, W. Kaplan and L. Ajello (eds.): Color atlas and text of the histopathology of mycotic diseases, Year Book Medical Publishers, Chicago 1980.
K. Salfelder, T.R.D. Liscano and E. Sauerteig (eds.): Atlas of fungal pathology, Kluwer Aca-demic Publishers, Dordrecht, Boston 1990.
A.J. Morris, T.C. Byrine, J.F. Madden, L.B. Reller: J. Clin. Microbiol. 34, 1583 (1996).
I. Weitzman and R C Summerbell: Clin. Microbiol. Rev. 8, 240 (1995).
J. Kane, R. Summerbell, L. Sigler, S. Krajden and G. Land (eds.): Laboratory Handbook of Dermatophytes, Star Publishing, Belmont CA 1997.
K. Tintelnot, G. Haase, M. Seibold, F. Bergmann, M. Staemmler, T. Franz and D. Nau-mann: J. Clin. Microbiol. 38, 1599 (2000).
C.P. Kurtzman and J.W. Fell (eds.): The yeasts, a taxonomic study, Elsevier, Amsterdam 1998.
A.M. Freydière, R. Guinet and P. Boiron: Med. Mycol. 39, 9 (2001).
G.S. de Hoog, J. Guarro, J. Gene and M.J. Figueras (eds.): Atlas of clinical fungi, Cen-traalbureau voor Schimmelcultures/Universitat Rovira i Virgili, Utrecht/Reus 2000.
D. Larone (ed.): Medically important fungi, ASM Press, Washington 2002.
L. Kaufman and P.G. Standard: Annu. Rev. Microbiol. 41, 209 (1987).
P. Hamal, R. Kappe and D. Rimek: J. Hosp. Infect. 49, 37 (2001).
P.M. Rath, G. Marggraf, H. Dermoumi and R. Ansorg: Mycoses 38, 429 (1995).
S.F. Yeo and B. Wong: Clin. Microbiol. Rev. 15, 465 (2002).
N. Bloomfield, M.A. Gordon and D.F. Elmendorf Jr.: Proc. Soc. Exp. Biol. Med. 114, 64 (1963).
D. Stynen, A. Goris, J. Sarfati and J.P. Latgè: J. Clin. Microbiol. 33, 497 (1995).
S. Bretagne, J.M. Costa, E. Bart-Delabesse, N. Dhedin, C. Rieux and C. Cordonnier: Clin. Infect. Dis. 26, 1407 (1998).
B. Sendid, M. Tabouret, J.L. Poirot, D. Mathieu, J. Fruit and D. Poulain: J. Clin. Micro-biol. 37, 1510 (1999).
T. Mori, H. Ikemoto, M. Matsumura, M. Yoshida, K. Inada, S. Endo, A. Ito, S. Watanabe, H. Yamaguchi, M. Mitsuya et al.: Eur. J. Clin. Chem. Clin. Biochem. 35, 553 (1997).
R. Kappe and H.P.R. Seeliger, in: M. Borgers, R. Hay and M.G. Rinaldi (eds.): Current top-ics in medical mycology, Vol. V, Prous Science, Barcelona 1993, 247–280.
J. Loeffler, N. Henke, H. Hebart, D. Schmidt, L. Hagmeyer, U. Schumacher and H. Ein-sele: J. Clin. Microbiol. 38, 586 (2000).
L. De Repentigny: Clin. Infect. Dis. 14 (Suppl. 1), Sll (1992).
R. Kappe, A. Schulze-Berge and H.-G. Sonntag: Mycoses 39, 13 (1996).
D.F. Palmer, L. Kaufmann, W. Kaplan and J.J. Cavallaro (eds.): Serodiagnosis of mycotic diseases, Thomas, Springfield, IL 1977.
L.J. Wheat: Semin. Respir. Infect. 16, 131 (2001).
J. P. Martinez, M.L. Gil, J.L. Lopez-Ribot and W. LaJean Chaffin: Clin. Microbiol. Rev. 11, 121 (1998).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Basel AG
About this chapter
Cite this chapter
Kappe, R., Rimek, D. (2003). Diagnosis of fungal diseases. In: Jucker, E. (eds) Antifungal Agents. Special Topic, vol 001. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7974-3_3
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7974-3_3
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-7643-6926-2
Online ISBN: 978-3-0348-7974-3
eBook Packages: Springer Book Archive