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Recent Advances in the Pathophysiology of COPD pp 61–74Cite as

Birkhäuser

Oxidative Stress in COPD

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Oxidative stress occurs when reactive oxygen species (ROS) are produced in excess of the antioxidant defence mechanisms and result in harmful effects, including damage to lipids, proteins and DNA. There is increasing evidence that oxidative stress is an important feature in inflammatory airway diseases, including chronic obstructive pulmonary disease (COPD) [1–3]. This area of research has received new impetus by the recent development of several techniques for measuring oxidative stress in the lungs [4]. However, the pathophysiological role of oxidative stress in airway diseases will only be firmly established when more potent antioxidants become available for clinical use.

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Authors and Affiliations

  1. National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK

    Peter J. Barnes

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  1. NHLI Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London, SW3 6HP, UK

    Trevor T. Hansel

  2. Department of Thoraic Medicine National Heart and Lung Institute, Imperial College, Dovehouse St., London, SW3 6LY, UK

    Peter J. Barnes

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Barnes, P.J. (2004). Oxidative Stress in COPD. In: Hansel, T.T., Barnes, P.J. (eds) Recent Advances in the Pathophysiology of COPD. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7939-2_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7939-2_5

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