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IL-17 as a contributor to inflammation and destruction in rheumatoid arthritis

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Cytokines and Joint Injury

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Therapeutic control of TNFαand IL-1 with specific inhibitors has clearly demonstrated the contribution of these cytokines to the destructive and inflammatory patterns associated with rheumatoid arthritis (RA). At the same time, the list of additional cytokines with similar biological effects has been growing extensively. Among these, IL-17 is of interest since it shares properties and interacts with TNF? and IL-1. In addition, being produced by T cells, demonstration of the contribution of IL-17 in arthritis would add some new information on the contribution of T cells to the pathogenesis of RA. These issues are important since they may lead to new therapeutic applications. Since this topic has been the subject of a recent review, we will focus on the latest developments [1].

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  1. Department of Immunology and Rheumatology, Hôpital Edouard Herriot, Lyon Cedex 03, 69437, France

    Pierre Miossec

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  1. Rheumatology Research Lab, University Medical Center Nijmegen, 189, Geert Grooteplein 26–28, Nijmegen, 6500 HB, The Netherlands

    Wim B. van den Berg

  2. Hôpital Edouard Herriot Service de Rhumatologie Unité d’Immunologie Clinique, Université Claude Bernard — Lyon 1, Lyon, 69437, France

    Pierre Miossec

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Miossec, P. (2004). IL-17 as a contributor to inflammation and destruction in rheumatoid arthritis. In: van den Berg, W.B., Miossec, P. (eds) Cytokines and Joint Injury. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7883-8_7

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  • DOI: https://doi.org/10.1007/978-3-0348-7883-8_7

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