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Drugs that target serotonergic receptors

  • Alvin V. TerryJr.
Part of the Milestones in Drug Therapy MDT book series (MDT)

Abstract

Of the neurotransmitter substances characterized to date, serotonin (5-hydroxytryptamine-5-HT) is perhaps one of the most extensively studied. Initial reports of its actions on smooth muscle appeared more than 50 years ago and it is now known to have widespread peripheral and central physiologic actions. In the periphery, the amine is released from platelets to activate clotting cascades and blood vessel constriction; in the gastrointestinal tract it inhibits gastric acid production and stimulates the contractions of smooth muscle [1]. In the central nervous system, 5HT is known to regulate or influence such diverse processes as activity patterns and circadian rhythm, food intake, sleep-wake cycles, aggressive behaviors, locomotion, thermoregulation, nociception, and sexual activity [2].

Keywords

Morris Water Maze Passive Avoidance 5HT4 Receptor Agonist Serotonergic Receptor 5HT4 Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 2004

Authors and Affiliations

  • Alvin V. TerryJr.
    • 1
  1. 1.Program in Clinical and Experimental TherapeuticsUniversity of Georgia College of Pharmacy (Augusta Campus) and Small Animal Behavior Core, Medical College of GeorgiaAugustaUSA

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