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Development of the first commercially available recombinant human bone morphogenetic protein (rhBMP-2) as an autograft replacement for spinal fusion and ongoing R&D direction

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Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

After several decades of promising research on bone morphogenetic proteins (BMPs), a product that surgeons can use clinically is now commercially available. More than two decades after Urist’s first observation of demineralized bone osteoinductivity in 1965, a single bone morphogenetic protein was isolated from bone and produced recombinantly (rhBMP-2) [1, 2]. The recombinant production of BMP-2 opened the door for the development of a commercial BMP product, since the extraction of these proteins from bone was not a viable commercial option.

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Author information

Authors and Affiliations

  1. Medtronic Sofamor Danek, 1800 Pyramid Place, Memphis, TN, 38132, USA

    Bill McKay

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  1. Bill McKay
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Editor information

Editors and Affiliations

  1. Laboratory for Mineralized Tissues, School of Medicine, Salata 11, Zagreb, HR, 10000, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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© 2004 Springer Basel AG

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McKay, B. (2004). Development of the first commercially available recombinant human bone morphogenetic protein (rhBMP-2) as an autograft replacement for spinal fusion and ongoing R&D direction. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: Regeneration of Bone and Beyond. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7857-9_8

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  • DOI: https://doi.org/10.1007/978-3-0348-7857-9_8

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9598-9

  • Online ISBN: 978-3-0348-7857-9

  • eBook Packages: Springer Book Archive

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