Abstract
Approximately six million fractures occur each year in the United States, of which 1.5 million involve long bones. These injuries produce considerable morbidity and impairment in individuals of both genders, all age groups and regardless of socioeconomic circumstances. On an annual basis, fractures account for over 36 million lost days from work, more than seven million days missed from school, approximately 6.4 million days of hospitalization, nearly 9.4 million visits to healthcare providers, and cost society an estimated US$ 21 billion [1]. Among the most problematic and burdensome fractures are those 5–10% that demonstrate delayed healing or nonunion [2].
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Friedlaender, G.E. (2004). Clinical experience of osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: Regeneration of Bone and Beyond. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7857-9_7
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DOI: https://doi.org/10.1007/978-3-0348-7857-9_7
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