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Biology of bone morphogenetic proteins

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Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

TGF-β superfamily of proteins consists of conserved families of signaling molecules. One of the largest of these multifunctional families is that of the bone morphogenetic proteins (BMPs), with more than 20 members identified in organisms ranging from sea urchin to mammals. BMPs were first named by the ability to induce ectopic cartilage and endochondral bone when implanted in experimental animals [1]. It is now clear that the name is misleading because there is strong evidence that these molecules regulate biological processes as diverse as cell proliferation, apoptosis, differentiation, cell fate determination and morphogenesis [2]. Besides skeleton, BMPs play a role in the development of other organ and tissue systems that form via mesenchymal-epithelial interactions and possibly function to deliver or interpret positional information in a wide variety of organisms [3, 4] (see the chapter by SimicNukicevic).

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Authors and Affiliations

  1. Department of Anatomy, Medical School, University of Zagreb, Salata 11, Zagreb, 10000, Croatia

    Snjezana Martinovic, Petra Simic, Fran Borovecki & Slobodan Vukicevic

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  1. Snjezana Martinovic
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  2. Petra Simic
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  3. Fran Borovecki
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  4. Slobodan Vukicevic
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  1. Laboratory for Mineralized Tissues, School of Medicine, Salata 11, Zagreb, HR, 10000, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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Martinovic, S., Simic, P., Borovecki, F., Vukicevic, S. (2004). Biology of bone morphogenetic proteins. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: Regeneration of Bone and Beyond. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7857-9_3

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  • DOI: https://doi.org/10.1007/978-3-0348-7857-9_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9598-9

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