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Remodeling of arachidonic acid in inflammatory cells of the human lung

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Arachidonate Remodeling and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Arachidonic acid (AA) is a key molecule in the modulation of several pathophysiological events in mammalian cells, including gene expression, membrane signal transduction, cell differentiation and apoptosis, exocytosis and generation of eicosanoids [1–4]. It has been now convincingly demonstrated that the intracellular levels of free AA within mammalian cells are crucial for most of these events and, therefore, they are carefully regulated by complex biochemical reactions [5, 6]. These reactions are catalyzed by enzymes involved in both AA mobilization and reesterification into the storage sites and transfer from one intracellular pool to another [7, 8].

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Authors and Affiliations

  1. Division of Clinical Immunology and Allergy, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy

    Massimo Triggiani, Giorgio Giannattasio, Francescopaolo Granata, Stefania Loffredo, Francesca W. Rossi & Gianni Marone

  2. Experimental Endocrinology and Oncology Institute “G. Salvatore”, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy

    Salvatore Salzano

Authors
  1. Massimo Triggiani
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  2. Giorgio Giannattasio
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  3. Francescopaolo Granata
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  4. Stefania Loffredo
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  5. Francesca W. Rossi
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  6. Salvatore Salzano
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  7. Gianni Marone
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Editors and Affiliations

  1. Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA, 91101-1830, USA

    Alfred N. Fonteh

  2. Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1016, USA

    Robert L. Wykle

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Triggiani, M. et al. (2004). Remodeling of arachidonic acid in inflammatory cells of the human lung. In: Fonteh, A.N., Wykle, R.L. (eds) Arachidonate Remodeling and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7848-7_7

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  • DOI: https://doi.org/10.1007/978-3-0348-7848-7_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9594-1

  • Online ISBN: 978-3-0348-7848-7

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