Abstract
For many years, lipids were long thought to be merely the bricks and mortar that composed cell membranes. However, in the past 20 years it has become evident that these molecules are not merely passive building blocks but contain information that can be unleashed when they are metabolized upon cell activation. The signaling properties of specific glycerophospholipids and their metabolites highlight the importance of lipid composition in cell homeostasis. For example, phospholipid to sterol ratios are tightly maintained and the loss of these ratios is thought to contribute to foam cell death and the progression of atherosclerosis [1, 2]. Different cell types not only vary in the relative abundance of each phospholipid class, but also in the fatty acyl composition within each class of phospholipids [3, 4].
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Barbour, S.E., Al-Darmaki, S., Manguikian, A.D. (2004). Phospholipase A2 and remodeling in inflammatory cells. In: Fonteh, A.N., Wykle, R.L. (eds) Arachidonate Remodeling and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7848-7_2
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DOI: https://doi.org/10.1007/978-3-0348-7848-7_2
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