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Asthma

  • Chapter
In Vivo Models of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Asthma is a highly regulated and complex disease process involving interactions between lung immunology, neural control, and inflammation that result in reversible early and/or late phase airflow obstruction, airway hyperreactivity, cellular infiltration, and histopathologic changes (e.g. mucus and bronchial smooth muscle cell hypertrophy). Much of our current understanding of this disease process, albeit incomplete, has been obtained through preclinical studies using in vivo models developed in a variety of species to target cellular, biochemical, and molecular mechanisms. Some of the more commonly used species that will be discussed in this review include mouse, guinea pig, rat, rabbit, sheep, dog, and primate. Excluded from this list due to practical considerations is the horse which commonly exhibits an allergic response (“heaves”) to hay mold spores [1]. Due to limitations of space, we have concentrated on the most recent applications, newer technologies, and drug therapies in these animal models whenever possible. Remember that no single animal model precisely mimics the human condition; however, each model helps advance the understanding of this complex disease process and establishes new, cost-effective therapeutic approaches.

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Authors and Affiliations

  1. Hoechst Marion Roussel, Inc., Route 202-206, P.O. Box 6800, Bridgewater, NJ, 08807-0800, USA

    William M. Selig

  2. Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033-0539, USA

    Richard W. Chapman

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  1. Cancer Research, Abbott Laboratories, D-47J AP9, 60064, Abbott Park, IL, USA

    Douglas W. Morgan Ph.D. (Senior Group Leader) (Senior Group Leader)

  2. Department of Immunology, SmithKline Beecham Pharmaceuticals, P.O. Box 1539, 19406, King of Prussia, PA, USA

    Lisa A. Marshall Ph.D. (Director and Head) (Director and Head)

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Selig, W.M., Chapman, R.W. (1999). Asthma. In: Morgan, D.W., Marshall, L.A. (eds) In Vivo Models of Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7775-6_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7775-6_5

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