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Angiogenesis

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In Vivo Models of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Angiogenesis is defined as the production of new blood vessels from pre-existing blood vessels. It is a carefully controlled process that occurs in a healthy individual only under specific conditions at specific times, such as during embryogenesis, wound healing, ovulation and menses. At other times, the vasculature is extremely stable, with very low rates of endothelial cell turnover and little production of new vessels [1]. However, there are pathological conditions in which angiogenesis occurs, examples being cancer, arthritis, ocular diseases, psoriasis [2–4]. In fact, the hypothesis has been proposed that many of these diseases depend on the new vasculature to provide a basis for their proliferation [5–7]. Thus, inhibition of angiogenesis is proposed to be a potential therapeutic approach to chronic proliferative diseases.

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Authors and Affiliations

  1. Department of Immunopharmacology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406, USA

    James D. Winkler & Jeffrey R. Jackson

  2. Department of Pharmacology, University of Cambridge, Cambridge, UK

    Tai-Ping Fan

  3. Panceutics Ltd, P.O. Box 11358, Swindon, Wilts, SN3 4GP, UK

    Michael P. Seed

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  1. James D. Winkler
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  2. Jeffrey R. Jackson
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  3. Tai-Ping Fan
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  4. Michael P. Seed
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Editors and Affiliations

  1. Cancer Research, Abbott Laboratories, D-47J AP9, 60064, Abbott Park, IL, USA

    Douglas W. Morgan Ph.D. (Senior Group Leader) (Senior Group Leader)

  2. Department of Immunology, SmithKline Beecham Pharmaceuticals, P.O. Box 1539, 19406, King of Prussia, PA, USA

    Lisa A. Marshall Ph.D. (Director and Head) (Director and Head)

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Winkler, J.D., Jackson, J.R., Fan, TP., Seed, M.P. (1999). Angiogenesis. In: Morgan, D.W., Marshall, L.A. (eds) In Vivo Models of Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7775-6_4

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