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Comparison of adjuvant and streptococcal cell wall-induced arthritis in the rat

  • Chapter
In Vivo Models of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The goals of this chapter are to discuss rat adjuvant and streptococcal cell wall-induced arthritis, both as animal models of chronic inflammation, and as relevant and predictive models of human rheumatoid arthritis (RA). The information which follows is intended to (1) provide the investigator with a detailed methodology for these two chronic models of inflammation, and (2) to review the pathogenesis and therapeutic interventions for which these models have historically been used to further our understanding of RA and its potential regulation by novel drugs. While these animal models have been extensively studied for over 30 years, the following information provides a rationale to better understand the similarities and differences of these models to RA. Furthermore, this chapter will describe how new technologies, such as magnetic resonance imaging (MRI), can be integrated with these “old” models to better predict clinical efficacy with the many new biological and immunomodulatory drugs currently in development.

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  1. Department of Immunological Disease Research, Abbott Laboratories, D4NB, AP-9, 100 Abbott Park Road, Abbott Park, IL, 60064-3500, USA

    Richard P. Carlson & Peer B. Jacobson

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  1. Cancer Research, Abbott Laboratories, D-47J AP9, 60064, Abbott Park, IL, USA

    Douglas W. Morgan Ph.D. (Senior Group Leader) (Senior Group Leader)

  2. Department of Immunology, SmithKline Beecham Pharmaceuticals, P.O. Box 1539, 19406, King of Prussia, PA, USA

    Lisa A. Marshall Ph.D. (Director and Head) (Director and Head)

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Carlson, R.P., Jacobson, P.B. (1999). Comparison of adjuvant and streptococcal cell wall-induced arthritis in the rat. In: Morgan, D.W., Marshall, L.A. (eds) In Vivo Models of Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7775-6_1

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  • DOI: https://doi.org/10.1007/978-3-0348-7775-6_1

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