Abstract
Neuroblastoma relapses associated with bone marrow infiltrations are considered a favorable therapeutic setting for radioimmunotherapy (RIT), because access of radiolabeled, tumor specific monoclonal antibodies (mAbs) is much better than in solid tumors. MAb chCE7 is a chimeric antibody directed against a neuroblastoma associated cell surface glycoprotein, which is internalized into its target cells (1) and first clinical results with 123 I and 131 I-labeled chCE7 have shown that it is taken up rapidly and strongly into bone marrow infiltrations (2,3).We plan to evaluate mAb chCE7 for RIT applications in such cases.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Novak-Hofer,I.,Amstutz,H.P., Haldemann,A., Blaser,K., Morgenthaler,J.J., Blaeuenstein,P., and Schubiger,P.A. (1992) Radioimmunolocalization of neuroblastoma xenografts with chimeric antibody chCE7. J.Nucl.Med. 33, 231–236.
Doerr,U., Haldemann,A.R., Leibundgut,K., Novak-Hofer,I., Amstutz,H., Wagner,H.P., Schubiger,P.A.Morgenthaler, J.J., Roesler,H., Schilling,F., Kscielniak,E.,Treuner,J.,and 3 3 3 Bihl,H. (1993) First clinical results with the chimeric antibody chCE7 in neuroblastoma. Targeting features and biodistribution data. Eur.J.Nucl.Med. 20, 858.
Haldemann,A.R.,Leibundgut,K., Doerr,U., Novak-Hofer,I., Amstutz,H.P., Wagner,H.P., Treuner,J., Bihl,H., Roesler,H. (1994) Radioimmunszintigraphie mit dem chimaeren Antikoerper CE7: erste klinische Erfahrungen. SGMR, 81. Jahresversammlung.
Smith-Jones,P.M.,Fridrich,R.,Kaden,T.A.,Novak-Hofer,I.,Siebold,K.,Tschudin,D.,and Maecke,H. (1991) Antibody labeling with copper-67 using the bifunctional macrocycle 4(1,4,8,11-tetraazacyclotetradec-1-yl)methyl) benzoic acid. Bioconjugate Chem. 2, 415–421.
Novak-Hofer,I.,Amstutz,H.P., Maecke,H.R., Schwarzbach,R., Zimmermann,K., Morgenthaler,J.J., and Schubiger,P.A. (1995) Cellular processing of copper-67-labeled monoclonal antibody chCE7 by human neuroblastoma cells. Cancer Res., 55, 46–50.
Buchegger,F.,Pellegrin,A.,Delaloye,B.,Bischof-Delaloye,A., and Mach,J.P. (1990) Iodine131-labeled mAbF(ab’)2 fragments are more efficient and less toxic than intact antiCEA antibodies in radioimmunotherapy of large human colon carcinoma grafted in nude mice. J.Nucl.Med. 31, 1035–1044.
Smith,A., Alberto,R., Blaeuenstein,P., Novak-Hofer,I., Maecke,H., and Schubiger,P.A. (1993) Preclinical evaluation of 67Cu-labeled intact and fragmented anti-colon carcinoma monoclonal antibody MAb35. Cancer Res. 53, 5727–5733.
Anderson,C.J., Schwarz,S.W., Connett,J.M., Cutler,P.D., Guo,L.W.,Wu,L., Germain,C.J., Philpott,G.W., Zinn, K.R., Greiner,D.P., Meares,C.F., and Welch,M.,J. (1995) Preparation, biodistribution and dosimetry of copper-64-labeled anti-colorectal carcinoma antibody fragments 1A3-F(ab’)2. J.Nucl.Med. 36, 850–858.
Novak-Hofer,I., Zimmermann,K., Maecke,H.R., Amstutz,H.P., Carrel,F., and Schubiger,P.A. (1996) Tumor uptake and metabolism of copper-67-labeled monoclonal antibody chCE7 in nude mice bearing neuroblastoma xenografts. J.Nucl.Med., in press.
Schwarzbach,R., Zimmermann,K., Blaeuenstein,P., Smith,A., and Schubiger,P.A. (1995) Developement of a simple and selective separation of 67Cu from irradiated zinc for use in antibody labeling: A comparison of methods. Appl.Radiat.Isot. 5, 329–336.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Basel AG
About this chapter
Cite this chapter
Novak-Hofer, I. et al. (1997). Copper-67 labeled mAb chCE7 as a potential therapeutic agent for neuroblastoma: improved biodistributions of copper-67-chCE7 F(ab’)2. In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_40
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7772-5_40
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7774-9
Online ISBN: 978-3-0348-7772-5
eBook Packages: Springer Book Archive