Summary
Schizophrenia and affective disorders are supposed to involve neural systems for information processing and biogenic amine transmission. In this context functional neuroimaging has been widely accepted for detecting possible cortical impairments. In our present study we performed functional neuroimaging using 99m Tc-ECD SPECT for a paradigm on smooth pursuit eye movement and compared the results with resting patterns. Saccadic intrusions were monitored during an electronystagmographic examination. Reduced neuroactivaton during smooth pursuit eye movement in subjects with an elevated rate of catch up saccades was found in centers of the frontal lobe (FEF). This might indicate an impairment of higher cortical motor control.
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References
Berman KF, Zec RF, Weinberger DR. Physiologic dysfunction of dorso-lateral prefrontal cortex in schizophrenia: II. role of neuroleptic treatment, attention, and mental effort. Arch Gen Psychiatry 1986; 43: 126–135.
Büttner-Ennever JA, editor. Reviews of Oculomotor Research, Volume 2: Neuro-anatomy of the Oculomotor System. Amsterdam-New York-Oxford: Elsevier, 1988.
Crawford TJ, Puri BK, Nijran KS, Jones B, Kennard C, Lewis SW. Ab-normal saccadic distractibility in patients with schizophrenia: a 99mTc-HMPAO SPECT study. Psychol Med 1996; in press.
Diefendorf AR, Dodge R. An experimental study of the ocular reaction of the insane from photographic records. Brain 1908; 31: 451–489.
Dolan RL, Bench CJ, Liddle FF, Friston KJ, Frith CD, Grasby PM, Frackowiak RSJ. Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity ? J Neurol Neurosurg Psychiatry 1993; 56: 1290–1294.
Franzén G, Ingvar DH. Absence of activation in frontal structures during psychological testing of chronic schizophrenics. J Neurol Neurosurg Psychiatry 1975; 38: 1027–1032.
Goldberg ME, Eggers HM, Gouras P. The ocular motor system. In: Principles of neural science. Third Edition, Kandel ER, Schwartz ill, Jessell TM, editors. New Jersey-London-Sydney-Toronto-Mexico City-New Delhi-Tokyo-Singapore-Rio de Janeiro: Prentice-Hall International Inc, 1991: 660–677.
Holzman PS, Proctor LR, Hughes DW. Eye tracking patterns in schizophrenia. Science 1973; 181: 179–181.
Ingvar, DH, Franzén G. Distribution of cerebral activity in chronic schizophrenia. Lancet 1974; 2: 1484–1486.
Nakashima Y, Momose T, Sano I, Katayama S, Nakajima T, Niwa SI, Matsushita M. Cortical control of saccade in normal and schizophrenic subjects: a PET study using a task-evoked rCBF paradigm. Schizophr Res 1994; 12: 259–264.
Weinberger DR, Bergman KF, Zec RF. Physiologic dysfunction of dorso-lateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 1986; 43: 114–124.
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Pinkert, J., Gerdsen, I., Fötzsch, R., Franke, WG., Oehme, L., Felber, W. (1997). Neuroactivation with SPECT and Smooth Pursuit Eye Movement in Schizophrenics. In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_16
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DOI: https://doi.org/10.1007/978-3-0348-7772-5_16
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7774-9
Online ISBN: 978-3-0348-7772-5
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