Summary
Single injection dual-phase MIBI thyroid scintigraphy was performed on 49 pts with a cold nodule on a previous Tc99m scintigraphy. In 8 pts the nodule displayed intense and persistent MIBI uptake (8 Hürthle cell tumors). In 23 pts the nodule displayed early intense uptake with late fading activity (9 benign and 14 malignant nodules). In 18 patients the nodule showed no MIBI uptake (3 malignant and 15 benign nodules). This tecnique is able to identify Hürthle cell tumors since they retain MIBI due to the presence of an abundant granular acidophilic cytoplasm represented by crowded mitochondria.
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Vattimo, A., Volterrani, D., Bertelli, P., Burroni, L., Vella, A. (1997). Hürthle Cell Tumor and Technetium-99m-Sestamibi Scintigraphy (Single Injection Double-Phase Study). In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_12
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DOI: https://doi.org/10.1007/978-3-0348-7772-5_12
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