Summary
In the follow up of 41 patients with thyroid cancer we found with the combined examination of 18FDG-WB PET and 131I-WB planar scans an alternating behavior of 131I- and 18FDG-uptake in the metastases like a Flipflop (Flipflop: Electronic device or a circuit, as in a computer, capable of assuming either of two stable states). The combination of 18FDG and 131I-Scanning has a high sensitivity of about 95%. This permits the detection of local recurrence or metastases in the WB-scan, which are often not shown by other imaging methods.Furthermore it seems to be possible to perform a biochemical grading of thyroid cancer with 18FDG and131I. Low grade tumors have low glucose metabolism, high grade tumors show high glucose metabolism. 131I uptake seems to be a sign for higher differentiation, 18FDG uptake for higher malignancy. Such a grading may also be possible in other tumors.
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© 1997 Springer Basel AG
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Feine, U., Lietzenmayer, R., Hanke, J.P., Wöhrle, H., Held, J., Müller-Schauenburg, W. (1997). 18FDG/131I-Alternating Uptake in Differentiated Thyroid Cancer — Whole Body PET in 41 Patients. In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_10
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DOI: https://doi.org/10.1007/978-3-0348-7772-5_10
Publisher Name: Birkhäuser, Basel
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