Skip to main content

Diglyceride, Protein Kinase C and Force Maintenance of Airways Smooth Muscle

  • Chapter
  • 62 Accesses

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

Over the past several years attempts have been made to elucidate many of the various biochemical events that take place during agonist-induced contraction and relaxation of airways smooth muscle. Such studies have clearly indicated that many processes are involved in the control of airways smooth muscle tone. In addition, there would appear to be considerable interplay between these biochemical events demonstrating the complexity of the contractile process.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berridge MJ Irvine RF. Inositol trisphosphate, a novel second messenger in signal transduction. Nature 1984; 312: 315–321.

    Article  PubMed  CAS  Google Scholar 

  2. Michel RH, Kirk CJ, Jones LM, Downes CP, Creba JA. The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions. Phil Trans R Soc B 1981; 296: 123–133.

    Article  Google Scholar 

  3. Berridge MJ. Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyze polyphosphoinositides instead of phosphatidylinositol. Biochem J 1983; 212: 849–858.

    PubMed  CAS  Google Scholar 

  4. Berridge MJ. Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 1984; 220: 345–360.

    PubMed  CAS  Google Scholar 

  5. Baron CB, Cunningham M, Strauss JF, Coburn RF. Pharmacomechanical coupling in smooth muscle may involve phosphatidylinositol metabolism. Proc Natl Acad Sci 1980; 81: 6899–6903.

    Article  Google Scholar 

  6. Grandordy BM, Cuss FM, Sampson AS, Palmer JB Barnes PJ. Phosphatidylinositol response to cholinergic agonists in airway smooth muscle: relationship to contraction and muscarinic receptor occupancy. J Pharmacol Exp Ther 1986; 238: 273–279.

    PubMed  CAS  Google Scholar 

  7. Grandordy BM, Barnes PJ. Phosphoinositide turnover in airway smooth muscle. Am Rev Resp Dis 1987; 136: 517–520.

    Google Scholar 

  8. Takuwa Y, Takuwa N, Rasmussen H. Carbachol induces a rapid and sustained hydrolysis of polyphosphoinositides in bovine tracheal smooth muscle. Measurements of the mass of polyphosphoinositides, 1,2-diacylglycerol and phosphatidic acid. J Biol Chem 1986; 261: 14670–14675.

    PubMed  CAS  Google Scholar 

  9. Takai Y, Kishimoto A, Kikkawa U, Mori T, Nishizuka Y. Unsaturated diacylglycerol as a possible messenger for the activation of calcium activated phospholipid dependent protein kinase system. Biochem Biophys Res Comm 1979; 91: 1218–1224.

    Article  PubMed  CAS  Google Scholar 

  10. Kishimoto A, Takai Y, Mori T, Kikkawa H, Nishizuka Y. Activation of calcium and phospholipid dependent protein kinase by diacylglycerol: its possible relation to phosphatidylinositol turnover. J Biol Chem 1980; 255: 2273–2276.

    PubMed  CAS  Google Scholar 

  11. Nishizuka Y. Calcium, phospholipid turnover and transmembrane signalling. Phil Trans R Soc Lond B 1983; 302: 101–112.

    Article  CAS  Google Scholar 

  12. Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 1984; 308: 693–698.

    Article  PubMed  CAS  Google Scholar 

  13. Kaibuchi K, Takai Y, Nishizuka Y. Cooperative roles of various membrane phospholipids in activation of calcium activated phospholipid-dependent protein kinase. J Biol Chem 1981; 256: 7146–7149.

    PubMed  CAS  Google Scholar 

  14. Rasmussen H, Barret PQ. Calcium messenger system: an integrated view. Physiol Rev 1984; 64: 98–984.

    Google Scholar 

  15. Rasmussen H, Takua Y, Park S. Protein kinase C in the regulation of smooth muscle contraction. FASEB J 1987; 1: 177–185.

    PubMed  CAS  Google Scholar 

  16. Bocckino SB, Blackmore PF, Wilson PB, Exton JH. Phosphatidate accumulation in hormone treated hepatocytes via phospholipase D mechanism. J Biol Chem 1987; 262: 15309–15315.

    PubMed  CAS  Google Scholar 

  17. Bocckino SB, Blackmore PF, Exton JH. Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine and angiotensin II. J Biol Chem 1985; 260: 14201–14207.

    PubMed  CAS  Google Scholar 

  18. Daniel LW, Waite M, Wykle RL. A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. J Biol Chem 1986; 261: 9128–9132.

    PubMed  CAS  Google Scholar 

  19. Qian Z, Drewes LR. Muscarinic acetylcholine receptor regulates phosphatidylcholine phospholipase D in canine brain. J Biol Chem 1989; 264: 21720–21724.

    PubMed  CAS  Google Scholar 

  20. Qian Z, Drewes LR. A novel mechanism for acetylcholine to generate diacylglycerol in brain. J Biol Chem 1990; 265: 3607–3610.

    PubMed  CAS  Google Scholar 

  21. Exton J. Mechanisms of action of calcium mobilizing agonists: some variations on a young theme. FASEB J 1988; 2: 2670–2676.

    PubMed  CAS  Google Scholar 

  22. Castagna M, Takai Y, Kaibuchi K, Sano K, Kittawa U, Nishizuka Y. Direct activation of calcium-activated phospholipid-dependent protein kinase by tumor promoting phorbol esters. J Biol Chem 1982; 257: 7847–7851.

    PubMed  CAS  Google Scholar 

  23. Cooper RA, Brunwald AD, Kuo AL. Phorbol ester induction of leukemic cell differentiation is a membrane-mediated process. Proc Natl Acad Sci 1982; 79: 2865–2869.

    Article  PubMed  CAS  Google Scholar 

  24. Divirgillio F, Lew DP, Pozzan T. Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels. Nature 1984; 310: 691–693.

    Article  Google Scholar 

  25. Wolf M., LeVine H, May S, Cuatrecasas P and Sayhoun N. A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters. Nature 1985; 317: 546–551.

    Article  PubMed  CAS  Google Scholar 

  26. Ebashi S. Regulation of muscle contraction. Natl Proc R Soc Lond B 1980; 207: 259–286.

    Article  CAS  Google Scholar 

  27. Morgan JP, Morgan KG. Vascular smooth muscle, the recorded transients. Pflugers Arch 1985; 395: 75–77.

    Article  Google Scholar 

  28. Bolton TB. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 1979; 59: 606–718.

    PubMed  CAS  Google Scholar 

  29. Kraft AS, Anderson WB. Phorbol esters increase the amount of Ca2+, phospholipiddependent protein kinase associated with the plasma membrane. Nature 1983; 301: 621–623.

    Article  PubMed  CAS  Google Scholar 

  30. Khalil RA, Morgan KG. Phenylephrine-induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret. J Physiol 1992; 455: 585–599.

    PubMed  CAS  Google Scholar 

  31. Schramm CM, Grundstein MM. Mechanisms of protein kinase C regulation of airway contractiltiy. J Appl Physiol 1989; 66: 1935–1941.

    Article  PubMed  CAS  Google Scholar 

  32. Dale MM, Obianime AW. 4β-PDBu contracts parenchymal strip and synergizes with raised cytosolic calcium. Eur J Pharmacol 1987; 141: 23–32.

    Article  PubMed  CAS  Google Scholar 

  33. Park S, Rasmussen H. Activation of tracheal smooth muscle contraction: synergism between Ca2+ and activators of protein kinase. C Proc Natl Acad Sci 1985; 82: 8835–8839.

    Article  CAS  Google Scholar 

  34. Langlands JM, Diamond J. Translocation of protein kinase C in bovine tracheal smooth muscle strips: the effect of methacholine and isoprenaline. Eur J Pharmacol 1992; 227: 131–138.

    Article  PubMed  CAS  Google Scholar 

  35. Hall IP, Chilvers ER. Inositol phosphates in airway smooth muscle. Pulm Pharmacol 1989; 2: 113–120.

    Article  PubMed  CAS  Google Scholar 

  36. Hall IP, Hill SJ. Inhibition by salbutamol, forskolin and IBMX of AlF4--induced inositol phosphate formation in bovine airway smooth muscle. Br J Pharmacol 1989; 98: 788P.

    Google Scholar 

  37. Hall IP, Donaldson J, Hill SJ. Inhibition of histamine-stimulated inositol phospholipid hydrolysis by agents which increase cyclic AMP levels in bovine tracheal smooth muscle. Br J Pharmacol 1989; 97: 603–613.

    Article  PubMed  CAS  Google Scholar 

  38. Langlands JM, Rodger IW, Diamond J. The effect of MB 22948 on methacholine and histamine-induced contraction and inositol 1,4,5-trisphosphate levels in guinea-pig tracheal tissue. Br J Pharmacol 1989; 98: 336–338.

    Article  PubMed  CAS  Google Scholar 

  39. Takuwa Y, Takuwa N, Rasmussen H. Measurement of cytoplasmic free Ca2+ concentrations in bovine tracheal smooth muscle using aqueorin. Am J Physiol 1987; 253: C817–827.

    PubMed  CAS  Google Scholar 

  40. Haller H, Smallwood JI, Rasmussen H. Protein kinase C translocation in intact vascular smooth muscle strips. Biochem J 1990; 270: 375–381.

    PubMed  CAS  Google Scholar 

  41. Secrest RJ, Lucaites VL, Mendelsohn LG, Cohen M. Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate. J Pharmacol Exp Ther 1991; 256: 103–109.

    PubMed  CAS  Google Scholar 

  42. Park S, Rasmussen H. Carbachol-induced protein phosphorylation changes in bovine tracheal smooth muscle. J Biol Chem 1986; 261: 15734–15739.

    PubMed  CAS  Google Scholar 

  43. Dale MM, Obianime AW. Phorbol myristate acetate causes in guinea pig lung parenchymal strips a maintained spasm resistant to isoprenaline. FEBS Lett 1985; 190: 6–10.

    Article  PubMed  CAS  Google Scholar 

  44. Obianime AW, Hirst SJ, Dale MM. Interactions between phorbol esters and agents which increase cytosolic calcium in the guinea-pig parenchymal strip: direct and indirect effects on the contractile responses. J Pharmacol Exp Ther 1988; 247: 262–270.

    PubMed  CAS  Google Scholar 

  45. Morrison KJ, Vanhoutte PM. Inhibition of airway smooth muscle tone by a phorbol etser in the guinea-pig trachea: role of epithelium and receptor reserve of the contractile agent. J Pharmacol Exp Ther 1991; 259: 198–204.

    PubMed  CAS  Google Scholar 

  46. Raeburn D. Do phorbol esters produce relaxation of tracheal muscle by generation of arachidonic acid from airway epithelium? Br J Pharmacol 1989; 98: 785P.

    Article  Google Scholar 

  47. Hootman SR, Brown ME, Williams JA. Phorbol esters and A23187 regulate Na+-K+ pump activity in pancreatic acinar cells. Am J Physiol 1987; 252: G49-G505.

    Google Scholar 

  48. Menkes H, Baraban JM, Snyder SH. Protein kinase C regulates smooth muscle tension in guinea-pig trachea and ileum. Eur J Pharmacol 1986; 122: 19–27.

    Article  PubMed  CAS  Google Scholar 

  49. Souhrada M, Souhrada JF. Sodium and calcium influx induced by phorbol esters in airway smooth muscle cells. Am Rev Resp Dis 1989; 139: 927–932.

    Article  PubMed  CAS  Google Scholar 

  50. Souhrada M and Souhrada JF. The role of protein kinase C in sensitization and antigen response of airway smooth muscle. Am Rev Resp Dis 1989; 140: 1567–1572.

    Article  PubMed  CAS  Google Scholar 

  51. Morrison KJ, Gao Y, Vanhoutte PM. Epithelium modulation of airway smooth muscle. Am J Physiol 1990; 258: L254–262.

    PubMed  CAS  Google Scholar 

  52. Flavahan NA, Aarhus LL, Riemele TJ, Vanhoutte PM. Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol 1985; 58: 834–838.

    PubMed  CAS  Google Scholar 

  53. Laitinen LA, Heino M, Laitinen A, Kava T and Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Resp Dis 1985; 131: 599–606.

    PubMed  CAS  Google Scholar 

  54. Spedding M. Interaction of phorbol esters with Ca2+ channels in smooth muscle. Br J Pharmacol 1987; 91: 377–384.

    Article  PubMed  CAS  Google Scholar 

  55. Fearon CW, Tashjian AH. lonomycin inhibits thyrotophin releasing hormone-induced translocation of protein kinase C in GH4C1 pituitary cells. J Biol Chem 1987; 262: 9515–9520.

    PubMed  CAS  Google Scholar 

  56. Izushi K, Tasaka, K. Ca2+-induced translocation of protein kinase C during Ca2+ dependent histamine release from Beta escin permeabilized rat mast cells. Pharmacology 1992; 44: 61–70.

    Article  PubMed  CAS  Google Scholar 

  57. O’Flaherty JT, Jacobson DP, Redman JF, Rossi AG. Translocation of protein kinase C in human polymorphonuclear neutrophils. J Biol Chem 1990; 265: 9146–9152.

    PubMed  Google Scholar 

  58. Trilivas I, Brown JH. Increases in intracellular Ca2+-regulates the binding of 3H-phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells. J Biol Chem 1989; 264: 3102–3107.

    PubMed  CAS  Google Scholar 

  59. Langlands JM, Diamond J. The effects of calcium on the translocation of protein kinase C in bovine tracheal smooth muscle. Eur J Pharmacol (Revision submitted).

    Google Scholar 

  60. Schachtele C, Wagner B, Rudolf C. Effect of Ca2+ entry blockers on myosin light chain kinase and protein kinase C. Eur J Pharmacol 1989; 163: 151–155.

    Article  PubMed  CAS  Google Scholar 

  61. Baraban JM, Gould RJ, Peroutka SJ, Snyder SA. Phorbol ester effects on neurotransmission: interaction with neurotransmitters and calcium in smooth muscle. Proc Natl Acad Sci 1985; 82: 604–607.

    Article  PubMed  CAS  Google Scholar 

  62. Brock TA, Rittenhouse SE, Powers CW, Ecstein LS, Gimbrone MA, Alexander RW. Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells. J Biol Chem 1985; 260: 14158–14162.

    PubMed  CAS  Google Scholar 

  63. Kotlikoff MI, Murray RK, Reynolds EE. Histamine-induced calcium release and phorbol antagonism in cultured airways smooth muscle cells. Am J Physiol 1987; 253: C561–0566.

    PubMed  CAS  Google Scholar 

  64. Murray RK, Bennet CF, Fluharty SJ, Kotlikoff MI. Mechanism of phorbol ester inhibition of histamine-induced IP3 formation in cultured airway smooth muscle. Am J Physiol 1989; 257: L209–216.

    PubMed  CAS  Google Scholar 

  65. Knox AJ, Clark J, Tattersfield AE. The effect of protein kinase C inhibition on histamine and methacholine-induced contraction of airway smooth muscle. Am Rev Resp Dis 1989; 139: A76.

    Google Scholar 

  66. Baron CB, Coburn RF. Phorbol ester modulates inositol phospholipid metabolism in carbamylcholine stimulated tracheal smooth muscle. Fed Proc 1987; 46: 704.

    Google Scholar 

  67. Murray RF, Kotlikoff MI. Multiple agonists couple to calcium release in cultured human airway smooth muscle cells. Am Rev Resp Dis 1989; 139: A469.

    Google Scholar 

  68. Hall IP, Donaldson J, Hill, SJ. Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors. Biochem Pharmacol 1990; 39: 1357–1363.

    Article  PubMed  CAS  Google Scholar 

  69. Langlands JM, Diamond J. The effect of phenylephrine on inositol 1,4,5-trisphosphate levels in vascular smooth muscle using a protein binding assay system. Biochem Biophys Res Commun 1990; 173: 1258–1265.

    Article  PubMed  CAS  Google Scholar 

  70. Pyne NJ, Murphy G, Milligan G, Houslay MD. Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein G. FEBS lett 1989; 243: 77–82.

    Article  PubMed  CAS  Google Scholar 

  71. Jakobs KH, Bauer S, Watanabe Y. Modulation of adenylate cyclase of human platelets by phorbol ester. Impairment of hormone-sensitive inhibitory pathways. Eur J Biochem 1985; 151: 425–430.

    Article  PubMed  CAS  Google Scholar 

  72. Pyne NJ, Shehnaz D, Rodger IW. Phorbol esters trigger the inactivation of the inhibitory guanine nucleotide binding protein (G) in airway smooth muscle. Biochem Soc Trans 1991; 19: 75S.

    Google Scholar 

  73. Pyne NJ, Shehnaz D, Rodger IW. Cholinergically-mediated inhibition of GTP-stimulated adenylate cyclase activity in airway smooth muscle. Am Rev Resp Dis 1991; 143: A549.

    Google Scholar 

  74. Pyne NJ, Grady MW, Shenaz D, Stevens PA, Pyne S, Rodger IW. Muscarinic blockade of beta-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins (Gs and Gi). Br J Pharmacol 1992; 107: 881–887.

    Article  PubMed  CAS  Google Scholar 

  75. Langlands JM, Rodger IW. The effects of methacholine and histamine on cyclic AMP-dependent protein kinase activity in guinea-pig isolated trachea. Can J Physiol Pharmacol 1992; 70: 344–348.

    Article  PubMed  CAS  Google Scholar 

  76. Langlands JM, Rodger IW. Determination of soluble cyclic AMP-dependent protein kinase activity in guinea-pig tracheal smooth muscle: preferential use of kemptide as a phosphorylating substrate. Biochem Pharmacol 1990; 39: 1365–1374.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Basel AG

About this chapter

Cite this chapter

Langlands, J.M., Schellenberg, R.R., Salari, H. (1994). Diglyceride, Protein Kinase C and Force Maintenance of Airways Smooth Muscle. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7681-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7681-0_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7683-4

  • Online ISBN: 978-3-0348-7681-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics