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Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation pp 271–308Cite as

Birkhäuser

Cyclic Nucleotide Phosphodiesterases in Airways Smooth Muscle

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Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

Bronchial asthma is a pulmonary disorder characterised by reversible airflow obstruction and mucosal inflammation [1]. The oedema and hypermucous secretion, which are major features of this inflammation, probably contribute to the compromised airways function; however, it is generally agreed that the predominant cause of the airflow obstruction is a powerful and inappropriate constriction of bronchial smooth muscle as a consequence of exposure of the airways to antigen or other noxious stimuli.

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Authors and Affiliations

  1. Discovery Biology, Rhône-Poulenc Rorer Ltd, Dagenham, Essex, United Kingdom

    John E. Souness

  2. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, England

    Mark A. Giembycz

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  1. John E. Souness
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  1. Department Head Discovery Biology, Rhône-Poulenc Rorer Ltd, Dagenham Research Centre, RM10 7XS, Dagenham, Essex, England

    David Raeburn

  2. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, England

    Mark A. Giembycz (Lecturer) (Lecturer)

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Souness, J.E., Giembycz, M.A. (1994). Cyclic Nucleotide Phosphodiesterases in Airways Smooth Muscle. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7681-0_13

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  • DOI: https://doi.org/10.1007/978-3-0348-7681-0_13

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