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Parasympathetic Innervation of Airways Smooth Muscle

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Airways Smooth Muscle

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

Nearly a century before the first accurate descriptions of the neuronal action potential were published [1, 2] and the chemical basis of synaptic transmission was firmly established [3, 4] studies carried out in isolated lungs and in the lungs of dead animals demonstrated that electrical stimulation of the vagus nerves elicited “pneumoconstriction”, or what we now recognize were contractions of the bronchial musculature and thus constriction of the airways [5, 6]. Today, more than 150 years since the publication of these pioneering studies, it is well established that the vagal innervation of the airways, and more specifically, the parasympa- thetic innervation of airways smooth muscle, is the primary means by which airways tone is regulated in all mammalian species including humans [6–8]. This observation, coupled with the belief that dysfunction of the parasympathetic innervation of the airways might contribute to various pulmonary disorders [8–13] has led to a continuous effort to determine the factors which influence parasympathetic input to the airways and the effects this input has on the physiology of the lungs in states of both health and disease.

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Authors and Affiliations

  1. Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Brendan J. Canning & Bradley J. Undem

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  1. Brendan J. Canning
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  2. Bradley J. Undem
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  1. Discovery Biology, Rhône-Poulenc Rorer Ltd, Dagenham Research Centre, Dagenham, Essex, RM10 7XS, England

    David Raeburn (Department Head) (Department Head)

  2. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, England

    Mark A. Giembycz (Lecturer) (Lecturer)

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Canning, B.J., Undem, B.J. (1994). Parasympathetic Innervation of Airways Smooth Muscle. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7558-5_3

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  • DOI: https://doi.org/10.1007/978-3-0348-7558-5_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7560-8

  • Online ISBN: 978-3-0348-7558-5

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