Purification, characterization and mechanism of action of scatter factor from human placenta

  • Madhu M. Bhargava
  • Yuan Li
  • Ansamma Joseph
  • Maryanne Pendergast
  • Regina Hofmann
  • Eliot M. Rosen
  • Itzhak D. Goldberg
Part of the Experientia Supplementum book series (EXS, volume 59)


Scatter factor (SF) causes contiguous sheets of epithelium to spread and cells to separate from each other. SF also increases the velocity, area, and reduces the circularity of individual cells. These changes are mediated in part by alterations in protein synthesis, protein phosphorylation, cytoskeletal reorganization, and cell surface components. SF has been purified from the conditioned medium of ras transformed 3T3 cells and human placenta. Sequence information suggests that SF from 3T3 cells is closely related to hepatocyte growth factor. SF is a glycoprotein, but glycosylation is not necessary for its activity. Glycosylation of target cell proteins, however, is required for SF action.


Conditioned Medium Hepatocyte Growth Factor Human Placenta Madin Darby Canine Kidney Scatter Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1991

Authors and Affiliations

  • Madhu M. Bhargava
    • 1
  • Yuan Li
    • 1
  • Ansamma Joseph
    • 1
  • Maryanne Pendergast
    • 1
  • Regina Hofmann
    • 1
  • Eliot M. Rosen
    • 1
    • 2
  • Itzhak D. Goldberg
    • 1
  1. 1.Department of Radiation Oncology, Long Island Jewish Medical CenterThe Long Island Campus of Albert Einstein College of MedicineNew Hyde ParkUSA
  2. 2.Department of Radiation TherapyYale University Medical SchoolNew HavenUSA

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