Neutrophil chemotactic factors

  • Liana Harvath
Part of the Experientia Supplementum book series (EXS, volume 59)


Polymorphonuclear leukocytes (neutrophils) are recruited to inflammatory sites by a variety of soluble mediators (chemoattractants) that stimulate neutrophil directed migration (Chemotaxis). Many neutrophil chemoattractants such as neutrophil activating proteins, leukotriene B4 (LTB4), platelet activating factor, and complement-derived C5a, are generated endogeneously by host cells or enzymatic cleavage of host proteins. Other chemoattractants such as N-formyl peptides are generated exogenously by bacteria that invade the host. Oxidative modification of methionine residues or changes in the amino acid sequence of peptide chemoattractants dramatically alter their chemoattractive properties. Many of the well-defined neutrophil chemotactic factors and studies of their structure-function relationships will be reviewed.


Human Neutrophil Chemotactic Factor Chemotactic Activity Neutrophil Chemoattractant Human Polymorphonuclear Leukocyte 
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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1991

Authors and Affiliations

  • Liana Harvath
    • 1
  1. 1.Division of Hematology, Center for Biologics Evaluation and ResearchFood and Drug AdministrationBethesdaUSA

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