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Neutrophil chemotactic factors

  • Liana Harvath
Chapter
Part of the Experientia Supplementum book series (EXS, volume 59)

Summary

Polymorphonuclear leukocytes (neutrophils) are recruited to inflammatory sites by a variety of soluble mediators (chemoattractants) that stimulate neutrophil directed migration (Chemotaxis). Many neutrophil chemoattractants such as neutrophil activating proteins, leukotriene B4 (LTB4), platelet activating factor, and complement-derived C5a, are generated endogeneously by host cells or enzymatic cleavage of host proteins. Other chemoattractants such as N-formyl peptides are generated exogenously by bacteria that invade the host. Oxidative modification of methionine residues or changes in the amino acid sequence of peptide chemoattractants dramatically alter their chemoattractive properties. Many of the well-defined neutrophil chemotactic factors and studies of their structure-function relationships will be reviewed.

Keywords

Human Neutrophil Chemotactic Factor Chemotactic Activity Neutrophil Chemoattractant Human Polymorphonuclear Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Birkhäuser Verlag Basel/Switzerland 1991

Authors and Affiliations

  • Liana Harvath
    • 1
  1. 1.Division of Hematology, Center for Biologics Evaluation and ResearchFood and Drug AdministrationBethesdaUSA

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