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Interleukin-6 stimulates motility of vascular endothelium

  • Eliot M. Rosen
  • David Liu
  • Eva Setter
  • Madhu Bhargava
  • Itzhak D. Goldberg
Chapter
Part of the Experientia Supplementum book series (EXS, volume 59)

Summary

Interleukin-6 (IL-6) is a cytokine which regulates host response to injury. Various preparations of recombinant human IL-6 stimulated migration of bovine brain and bovine aortic endothelial cells, with maximal responses at 100-600 ng/ml. The migration response was inhibited by anti-IL-6 monoclonal antibody. IL-6 also inhibited endothelial cell proliferation in a dose-dependent fashion. Combinations of IL-6 and tumor necrosis factor induced additive stimulation of migration. Studies with inhibitors and stimulators of various metabolic processes suggest that IL-6-induced motility: 1) does not require a pertussis toxin-sensitive G-protein, protein kinase C, or DNA synthesis; and 2) is regulated differently from the motility induced by scatter factor. A possible role for IL-6 in the regulation of physiologic angiogenesis is discussed.

Keywords

Scatter Factor Bovine Aortic Endothelial Cell Human Breast Carcinoma Cell Line Microcarrier Bead Endothelial Cell Motility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1991

Authors and Affiliations

  • Eliot M. Rosen
    • 1
  • David Liu
    • 2
  • Eva Setter
    • 1
  • Madhu Bhargava
    • 3
  • Itzhak D. Goldberg
    • 3
  1. 1.Department of Therapeutic RadiologyYale University School of MedicineNew HavenUSA
  2. 2.Cetus CorporationEmeryvilleUSA
  3. 3.Department of Radiation OncologyLong Island Jewish Medical CenterNew Hyde ParkUSA

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