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Tumor cell autocrine motility factor receptor

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Cell Motility Factors

Part of the book series: Experientia Supplementum ((EXS,volume 59))

Summary

The ability to locomote and migrate is fundamental to the acquisition of invasive and metastatic properties by tumor cells. Autocrine motility factor (AMF) is a cytokine produced by various tumor cells which stimulates their in vitro motility and in vivo lung-colonizing ability. AMF stimulates cell motility via a receptor-mediated signalling pathway. Signal transduction following binding of AMF to its receptor, a cell surface glycoprotein of 78 kD (gp78), is mediated by a pertussis toxin sensitive G protein, inositol phosphate production and the phosphorylation of gp78. AMF induces gp78 internalization to intracellular tubulovesicles and transport to the leading edge stimulating pseudopodial protrusion and cell motility.

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Authors and Affiliations

  1. Cancer Metastasis Program, Michigan Cancer Foundation, 48201, Detroit, MI, USA

    Ivan R. Nabi, Hideomi Watanabe, Steve Silletti & Avraham Raz

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  1. Ivan R. Nabi
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  2. Hideomi Watanabe
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  3. Steve Silletti
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  4. Avraham Raz
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Editors and Affiliations

  1. Department of Radiation Oncology, Long Island Jewish Medical Center, 270-05 76th Avenue, 11042, New Hyde Park, NY, USA

    I. D. Goldberg M.D.

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© 1991 Birkhäuser Verlag Basel/Switzerland

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Nabi, I.R., Watanabe, H., Silletti, S., Raz, A. (1991). Tumor cell autocrine motility factor receptor. In: Goldberg, I.D. (eds) Cell Motility Factors. Experientia Supplementum, vol 59. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7494-6_11

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  • DOI: https://doi.org/10.1007/978-3-0348-7494-6_11

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7496-0

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