Cell motility, a principal requirement for metastasis
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In studying the role of motility in the metastasis of tumor cells, we have described an autocrine motility factor. This agent, which stimulates random motility, probably contributes to the initial dissociation of the cells from the primary tumor mass. Extracellular matrix components, via several different mechanisms, may facilitate the crossing of biological barriers by the cells prior to the entry into the circulation. In locating at new sites, the tumor cells may be induced to exit from the circulation in reponse to attractants such as the IGFs that could emanate from the target organ. These same growth factors could then stimulate cellular proliferation for another metastatic cycle. It is quite probable that detection of AMF may provide a new tool in cancer diagnosis. The complete characterization of AMF may also yield valuable therapeutic approaches: design of low molecular size antagonists of the attractants and antibodies that might be effective therapeutically as well as diagnostically. It seems clear, in any event, that immobilizing the tumor cell may be a crucial step in inhibiting metastasis.
KeywordsA2058 Cell Melanoma Cell Pertussis Toxin Human Melanoma Cell Motility Response
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- Garcia-Castro, L, Mato, J. M., Vasanthakumar, G., Wiesmann, W. P., Schiffmann, E., and Chiang, P. K. (1983) Paradoxical effects of adenosine on neutrophil Chemotaxis. J. Biol. Chem. 258: 4345–4349.Google Scholar
- Papaconstantinou, J., and Colowick, S. P. (1961a) The role of glycolysis in the growth of tumor cells I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor cells in vitro. J. Biol. Chem. 236: 278–284.Google Scholar
- Papaconstantinou, J., and Colowick, S. P. (1961b) The role of glycolysis in the growth of tumor cells II. The effects of oxamic acid on the growth of HeLa cells in tissue culture. J. Biol. Chem. 236: 285–288.Google Scholar
- Stracke, M. L., Engel, J. D., Wilson, L. W., Rechler, M. M., Liotta, L. A., and Schiffmann, E. (1989) The type I Insulin-like growth factor receptor is a motility receptor in human melanoma cells. J. Biol. Chem. 264: 21544–21549.Google Scholar