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Effects of Nicotine on Biological Systems pp 57–61Cite as

Pharmacokinetics of Nicotine after Intranasal Administration

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Part of the book series: APS Advances in Pharmacological Sciences ((APS))

Summary

Using a capillary gas chromatographic method, plasma levels of nicotine was monitored after intranasal administration of nicotine to rats and humans. In the first study nicotine was administered intranasally to rats and a pH-dependent absorption was observed. In the second, the bioavailability of nicotine at a physiological pH was examined in man after application to different anatomical regions of the nose. The absorption was rapid and a high absolute bioavalability was found for nasal nicotine.

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Author information

Authors and Affiliations

  1. Drug Development, Pharmacia AB, Box 941, SE-251 09, Helsingborg, Sweden

    P. Olsson, F. Kuylenstierna, C-J. Johansson, PO. Gunnarsson & M. Bende

  2. ENT-dept, Central Hospital, SE-541 85, Skövde, Sweden

    P. Olsson, F. Kuylenstierna, C-J. Johansson, PO. Gunnarsson & M. Bende

Authors
  1. P. Olsson
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  2. F. Kuylenstierna
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  3. C-J. Johansson
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  4. PO. Gunnarsson
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  5. M. Bende
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Olsson, P., Kuylenstierna, F., Johansson, CJ., Gunnarsson, P., Bende, M. (1991). Pharmacokinetics of Nicotine after Intranasal Administration. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_8

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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