Summary
Nicotine (0.8mg/kg in saline) was given to rats in one or two daily doses by subcutaneous injection. Tyrosine hydroxylase activities were increased relative to saline controls in noradrenergic cell bodies in the locus coeruleus 7 days later and in noradrenergic terminals in the hypothalamus and hippcampus after 21 days, a pattern consistent with enzyme induction. These increases were of the same magnitude as when nicotine was given by daily injection for the full 7 or 21 days, implying that as little as a single dose of nicotine is as effective as chronic nicotine administration in increasing tyrosine hydroxylase activity in noradrenergic neurones.
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© 1991 Birkhäuser Verlag Basel
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Smith, K.M., Joseph, M.H., Gray, J.A. (1991). A Single Dose of Nicotine is Sufficient to Increase Tyrosine Hydroxylase Activity in Noradrenergic Neurones. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_45
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DOI: https://doi.org/10.1007/978-3-0348-7457-1_45
Publisher Name: Birkhäuser Basel
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