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Increased Sensitivity of Brain Muscarinic Receptor to its Agonists as a Result of Repeated Nicotine Pretreatment in Rats, Mice and Rabbits

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Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

Summary

In gallamine-immobilized and artificially ventilated rats, the dose-reponse curves of M-agonists and AntiChE rather than GABA or glycine receptor antagonists inducing EEG seizures shifted leftward after the brain nAChR was desensitized by acute or chronic nicotine pretreatment. This phenomenon could be prevented by N-antagonist mecamylamine.Similar results were obtained in acute nicotine tolerant mice and rabbits.In addition, the effect of M-agonist arecoline for producing brain mAChR down-regulation was potentiated in acute nicotine tolerant rats. Apparent dissociation constant values of brain mAChR high-affinity site to its agonists arecoline and oxotremorine were decreased in the presence of nicotine. It is concluded that brain nAChR desensitization as a result of repeated nicotine pretreatment selectively increases the sensitivity of brain mAChR high affinity binding sites to its agonists.

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Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, P.O.Box 130, Beijing, 100850, China

    Hai Wang & Chuan-gui Liu

Authors
  1. Hai Wang
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  2. Chuan-gui Liu
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Wang, H., Liu, Cg. (1991). Increased Sensitivity of Brain Muscarinic Receptor to its Agonists as a Result of Repeated Nicotine Pretreatment in Rats, Mice and Rabbits. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_37

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_37

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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