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Glucose Metabolism: An Index of Nicotine Action in the Brain

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Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

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Summary

Several experimental approaches have been used to delineate the initial sites and the distributions of action of nicotine in the brain. Radioligand binding studies have revealed a heterogeneous distribution of high affinity, specific binding sites for nicotine in brain. Other studies have employed metabolic mapping with 2-deoxy-D-[l-14C]glucose (DG) to measure of the regional cerebral metabolic rate(s) for glucose (rCMRglc). In rats, l-nicotine stimulates rCMRglc in brain areas which contain specific binding sites for [3H]nicotine, indicating that the sites are true receptors, linked to functional activity. Affected areas include limbic structures, components of the visual system, brain stem nuclei important in cardiovascular reflexes, and areas involved in motor function. In general, rats show tolerance to the effects of nicotine on rCMRglc. The distribution of in vivo effects of nicotine on rCMRglc implicates various brain regions in the behavioral and physiological effects of the drug.

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Authors and Affiliations

  1. Neuropharmacology Laboratory, Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, P.O. Box 5180, Baltimore, MD, 21224, USA

    Edythe D. London

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  1. Edythe D. London
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Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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London, E.D. (1991). Glucose Metabolism: An Index of Nicotine Action in the Brain. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_34

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_34

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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