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Desipramine Inhibits the Nicotine-Induced Exocytosis in Rat Phaeochromocytoma Cells (PC12)

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Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

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Summary

In clonal PC12 cells (differentiated with nerve growth factor), nicotine (100 µmol/1) induces exocytotic release of 3H-noradrenaline, since release (1) depends absolutely on the presence of extracellular calcium and (2) is associated with release of neuropeptide Y. The tricyclic antidepressant desipramine potently inhibits nicotine-induced noradrenaline release. However, desipramine is a much less potent inhibitor when release is elicited by the calcium ionophore A23187 or by potassium-induced depolarization. Desipramine most probably blocks the nicotinic acetylcholine receptor or the receptor-related cation channel.

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Author information

Authors and Affiliations

  1. Dept. of Pharmacology, University of Würzburg, Versbacherstr. 9, 8700, Würzburg, Germany

    S. Baunach, H. Russ & E. Schömig

  2. Dept. of Anaesthesiology, University of Würzburg, Germany

    H. G. Kress

  3. Dept. of Cardiology, University of Heidelberg, Germany

    M. Haass, G. Richardt & A. Schömig

Authors
  1. S. Baunach
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  2. H. Russ
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  3. M. Haass
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  4. G. Richardt
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  5. H. G. Kress
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  6. A. Schömig
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  7. E. Schömig
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Baunach, S. et al. (1991). Desipramine Inhibits the Nicotine-Induced Exocytosis in Rat Phaeochromocytoma Cells (PC12). In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_33

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_33

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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