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Prenatal Nicotine Exposure and Sexual Brain Differentiation

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Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

Summary

Drugs may interfere with the organizing action of circulating hormones such as gonadal and adrenal steroids on the developing brain and by this mechanism induce long-lasting alterations in brain function. In the rat, prenatal exposure to nicotine on gestational days 12–19 affects sexually dimorphic behavior and causes sex-dependent neurochemical changes. Prenatal nicotine suppresses a characteristic peak of plasma testosterone in the male rat fetus and results in depressed, female-like activity of brain aromatase which converts testosterone to estradiol, at a particular, early postnatal (PN) stage (PN 6).

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Author information

Authors and Affiliations

  1. Institute of Pharmacology, University of Zürich, Zürich, Switzerland

    W. Lichtensteiger, N. von Ziegler & M. Schlumpf

Authors
  1. W. Lichtensteiger
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  2. N. von Ziegler
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  3. M. Schlumpf
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Lichtensteiger, W., von Ziegler, N., Schlumpf, M. (1991). Prenatal Nicotine Exposure and Sexual Brain Differentiation. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_32

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_32

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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