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Cardiovascular Effects of Repeated Nicotine Administrations: Conditions where Effects are Maintained or where Self-Blockade Takes Place

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Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

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Summary

The pharmacologic conditions were examined where repeated doses of nicotine produce either sustained stimulant effects or self-blockade on the cardiovascular system. Repeated nicotine showed quantitatively maintained effects in unanesthetized spinal rats, at a dose range from 0.025 to 0.4 mg/kg i.v. Sodium pentobarbital (60 mg/kg i.p.) produced a tenfold decrease in sensitivity to single initial doses of nicotine and thus brought about a requirement of larger doses for cardiovascular stimulation. Nicotine self-blockade was observed only with very large doses under special conditions of pentobarbital anesthesia.

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References

  • Acheson, G.H. (1954) In: Pharmacology in Medicine (V.A. Drill, Ed.), McGraw-Hill, New York, pp 29/1–29/11.

    Google Scholar 

  • Benowitz, N.L. (1986) Ann. Rev. Med. 37, 21–32.

    Article  Google Scholar 

  • Cruz, S.L., Salazar, L.A., and Villarreal, J.E. (1988) Memorias del XII Congreso Nacional de Farmacologia, Mexico, p 152.

    Google Scholar 

  • Dale H.H. (1914) J. Pharmacol. Exp. Ther. 6, 147–190.

    Google Scholar 

  • Domino, E.F. (1967) Ann. N.Y. Acad. Sci. 142, 216–244.

    Article  Google Scholar 

  • Goldstein, A., Aronow, L. and Kalman, S.M. (1974) Principles of Drug Action, John Wiley & Sons, Inc., New York.

    Google Scholar 

  • Holbrook, J.H. (1987) In: Harrison’s Principles of Internal Medicine, 11th ed. McGraw-Hill, New York, pp 855–858.

    Google Scholar 

  • Kachur, J.F., May, E.L., Awaya, H., Egle, J.L., Aceto, M.D. and Martin, B.R. (1986) Life Sci. 38, 323 - 330.

    Article  Google Scholar 

  • Langley, J.N. and Dickinson, W.L. (1889) Proc. Roy. Soc. B. 46, 423–431.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Sección de Terapéutica Experimental, CINVESTAV, IPN., Apartado Postal 22026, 14000, México, D.F., México

    S. L. Cruz, L. A. Salazar & J. E. Villarreal

Authors
  1. S. L. Cruz
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  2. L. A. Salazar
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  3. J. E. Villarreal
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Cruz, S.L., Salazar, L.A., Villarreal, J.E. (1991). Cardiovascular Effects of Repeated Nicotine Administrations: Conditions where Effects are Maintained or where Self-Blockade Takes Place. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_27

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_27

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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